Microglia are brain myeloid cells that play a critical role in neuroimmunity and the etiology of
Alzheimer's disease (AD), yet our understanding of how the genetic regulatory landscape …

Microglia have emerged as important players in brain aging and pathology. To understand
how genetic risk for neurological and psychiatric disorders is related to microglial function …

Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease
(AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene …

Microglia are emerging as a key cell type in neurodegenerative diseases, yet human
microglia are challenging to study in vitro. We developed an in vitro cell model system …

Background Amongst risk alleles associated with late-onset Alzheimer's disease (AD), those
that converged on the regulation of microglia activity have emerged as central to disease …

Advances in human genetics have implicated a growing number of genes in
neurodegenerative diseases, providing insight into pathological processes. For Alzheimer …

Candidate cis-regulatory elements (cCREs) in microglia demonstrate the most substantial
enrichment for Alzheimer's disease (AD) heritability compared to other brain cell types …

Recent work has identified dozens of non-coding loci for Alzheimer's disease (AD) risk, but
their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here …

Genome-wide association studies (GWAS) have identified more than 40 loci associated with
Alzheimer's disease (AD), but the causal variants, regulatory elements, genes and pathways …

Microglia, the tissue-resident macrophages of the central nervous system (CNS), play critical
roles in immune defense, development and homeostasis. However, isolating microglia from …