The cooperative nature of bone remodeling requires efficient means of intercellular
recognition, adhesion, and communication that allow cells to sort and migrate, synchronize …

Publisher Summary The organization of cells in tissues and organs is controlled by
molecular programs that afford cells the ability to recognize other cells and the extracellular …

Bone development (modeling) occurs by migration, aggregation, and condensation of
immature osteo/chondroprogenitor cells to form the cartilaginous anlage. This process …

Communication between osteoblasts, osteoclasts, and osteocytes is integral to their ability to
build and maintain the skeletal system and respond to physical signals. Various …

Publisher Summary This chapter reviews the role of direct cell–cell interactions in the
development and remodeling of the skeletal tissue, and focuses on the cell–cell adhesion …

Coordinated actions of osteoblasts and osteoclasts are required to maintain the integrity of
the skeleton. This is achieved, in part, by a highly regulated array of molecules that are …

Publisher Summary This chapter discusses the cell-cell communication in bone. Direct cell-
to-cell interactions via anchoring and communicating or “gap” junctions are general biologic …

It is generally accepted that cell-matrix and cell-cell interactions play a critical regulatory role
in the physiology of bone tissue. Interactions of bone cells with extracellular matrix have …

Endochondral bone formation requires an elaborate interplay among autocrine, paracrine,
and endocrine signals, positional cues, and cell‐cell contacts to mediate the complex three …

We have characterized the distribution, expression, and hormonal regulation of gap
junctions in primary cultures of rat osteoblast‐like cells (ROBs), and three osteosarcoma cell …