Blood glucose levels are tightly controlled by the coordinated action of at least four cell types
constituting pancreatic islets. Changes in the proportion and/or function of these cells are …

Elucidating the pathophysiology and molecular attributes of common disorders as well as
developing targeted and effective treatments hinges on the study of the relevant cell type …

Pancreatic islet cells are critical for maintaining normal blood glucose levels, and their
malfunction underlies diabetes development and progression. We used single-cell RNA …

Pancreatic islets consist of multiple cell types that produce hormones required for glucose
homeostasis, and islet dysfunction is a major factor in type 1 and type 2 diabetes. Numerous …

Hormone-secreting cells within pancreatic islets of Langerhans play important roles in
metabolic homeostasis and disease. However, their transcriptional characterization is still …

Identifying cis-regulatory elements is important to understanding how human pancreatic
islets modulate gene expression in physiologic or pathophysiologic (eg, diabetic) conditions …

Background Single-cell RNA sequencing (scRNA-seq) provides valuable insights into
human islet cell types and their corresponding stable gene expression profiles. However …

Genome-wide association studies (GWAS) have identified> 100 independent SNPs that
modulate the risk of type 2 diabetes (T2D) and related traits. However, the pathogenic …

Abstract Objective Type 2 diabetes (T2D) is a complex disease characterized by pancreatic
islet dysfunction, insulin resistance, and disruption of blood glucose levels. Genome-wide …

Genetic variation can modulate gene expression, and thereby phenotypic variation and
susceptibility to complex diseases such as type 2 diabetes (T2D). Here we harnessed the …