Notch in the kidney: development and disease

Y Sirin, K Susztak - The Journal of pathology, 2012 - Wiley Online Library
Notch signalling is a highly conserved cell–cell communication mechanism that regulates
development, tissue homeostasis, and repair. Within the kidney, Notch has an important …

Notch signaling in kidney development

B McCright - Current opinion in nephrology and hypertension, 2003 - journals.lww.com
Notch signaling in kidney development : Current Opinion in Nephrology and Hypertension
Notch signaling in kidney development : Current Opinion in Nephrology and Hypertension Log …

[HTML][HTML] Notch signaling in kidney development, maintenance, and disease

M Mukherjee, E Fogarty, M Janga, K Surendran - Biomolecules, 2019 - mdpi.com
Kidney development involves formation of nephrons intricately aligned with the vasculature
and connected to a branched network of collecting ducts. Notch signaling plays multiple …

[HTML][HTML] Kick it up a notch: Notch signaling and kidney fibrosis

MT Sweetwyne, J Tao, K Susztak - Kidney international supplements, 2014 - Elsevier
Notch is a critical regulator of kidney development, but the pathway is mostly silenced once
kidney maturation is achieved. Recent reports demonstrated increased expression of Notch …

The role of Notch signaling in kidney development and disease

H Barak, K Surendran, SC Boyle - Notch signaling in embryology and …, 2012 - Springer
The kidney is the body's filter, responsible for the removal of metabolic waste and the
excretion or reabsorption of electrolytes to control blood composition and pH balance. The …

Notch signaling in diabetic nephropathy

R Bonegio, K Susztak - Experimental cell research, 2012 - Elsevier
Notch signaling is an evolutionarily conserved cell–cell signaling system that controls the
fate of cells during development. In this review, we will summarize the literature that notch …

Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation

E Chung, P Deacon, JS Park - Development, 2017 - journals.biologists.com
Notch signaling plays important roles during mammalian nephrogenesis. To investigate
whether Notch regulates nephron segmentation, we performed Notch loss-of-function and …

The story of Notch and chronic kidney disease

S Sharma, Y Sirin, K Susztak - Current opinion in nephrology and …, 2011 - journals.lww.com
The story of Notch and chronic kidney disease : Current Opinion in Nephrology and
Hypertension The story of Notch and chronic kidney disease : Current Opinion in Nephrology …

[HTML][HTML] Expression of Notch pathway proteins correlates with albuminuria, glomerulosclerosis, and renal function

M Murea, JK Park, S Sharma, H Kato, A Gruenwald… - Kidney international, 2010 - Elsevier
Recent studies indicate that the Notch signaling pathway plays an important role in the
development of diabetic kidney disease and focal segmental glomerulosclerosis (FSGS) …

Ectopic notch activation in developing podocytes causes glomerulosclerosis

AM Waters, MYJ Wu, T Onay, J Scutaru… - Journal of the …, 2008 - journals.lww.com
Genetic evidence supports an early role for Notch signaling in the fate of podocytes during
glomerular development. Decreased expression of Notch transcriptional targets in …