Polymeric microneedle (MN) systems are interesting transdermal drug delivery systems
because of their controlled drug delivery, tunable properties, and ease of patient self …

The intrinsic properties of therapeutic proteins generally present a major impediment for
transdermal delivery, including their relatively large molecule size and susceptibility to …

In recent years, transdermal drug delivery based on microneedles (MNs) technology has
received extensive attention, which offers a safer and painless alternative to hypodermic …

A microneedle system has been developed to deliver chemical and biological agents
through the stratum corneum, which is the main barrier to drug delivery. Recently …

Dissolvable transdermal microneedles (μND) are promising micro-devices used to transport
a wide selection of active compounds into the skin. To provide an effective therapeutic …

Microneedles are one of the most prominent approaches capable of physically disrupting
the stratum corneum without devastating the deeper tissues to deliver both small molecules …

Human skin is a multilayered physiochemical barrier protecting the human body. The
stratum corneum (SC) is the outermost keratinized layer of skin through which only …

Many promising therapeutic agents are limited by their inability to reach the systemic
circulation, due to the excellent barrier properties of biological membranes, such as the …

Transdermal drug delivery is contemplated as one of the top appealing routes for
pharmaceutically active ingredients administration owing to the several benefits, specifically …

As non-toxic, biodegradable, biocompatible materials, the polymeric microneedles have a
great significance in terms of delivering therapeutic drug molecules through the skin. They …