Rai/ShcC is a member of the Shc family of protein adaptors expressed with the highest
abundance in the central nervous system, where it exerts a protective function by coupling …

Protein adapters couple surface receptors to multiple intracellular signaling modules by
acting as scaffolds for the assembly of multimolecular complexes responsible for the …

Rai (ShcC) belongs to the family of Shc adaptor proteins and is expressed in neuronal cells,
where it acts as a survival factor activating the PI3K/Akt survival pathway. In vivo, Rai …

T cell receptor (TCR) recognition of a peptide antigen in the context of MHC molecules
initiates positive and negative cascades that regulate T cell activation, proliferation and …

The antigen receptors on T and B lymphocytes (TCR and BCR) are multimeric complexes
composed of a receptor module associated with various signaling proteins (CD3 γδε, and …

Rai prevents lupus nephritis by impairing the development and expansion of both
proinflammatory Th17 and Th1 cells. Rai, a Shc adapter family member, acts as a negative …

The Shc adapter family includes four members that are expressed as multiple isoforms and
participate in signaling by a variety of cell‐surface receptors. The biological relevance of Shc …

The Shc family of adaptor proteins is a group of proteins that lacks intrinsic enzymatic
activity. Instead, Shc proteins possess various domains that allow them to recruit different …

The adapter protein Shc has been implicated in mitogenic signaling via growth factor
receptors, antigen receptors and cytokine receptors. Recent studies have suggested that …

Four non-enzymatic proteins form the structural core of the TCR signaling machinery, linking
antigen-receptor activation to signaling. These four proteins, each with well defined protein …