Antigen recognition within immunological synapses triggers and sustains T cell activation by
nucleating protein microclusters that gather T cell receptors (TCRs), kinases, and adaptors …

The adaptor molecule SLAP and E3 ubiquitin ligase c-Cbl each regulate expression of T cell
receptor (TCR)–CD3 on thymocytes. Here we provide genetic and biochemical evidence …

p46Shc and p52Shc become heavily tyrosine phosphorylated in response to interleukin 3
(IL-3) treatment. We have investigated the potential of Shc to integrate IL-3 signalling …

Shc family signalling adaptors connect activated transmembrane receptors to proximal
effectors, and most also contain a sequence involved in clathrin-mediated receptor …

Although signal transduction by immunoreceptors such as the T cell antigen receptor (TCR),
B cell antigen receptor (BCR), and Fc receptors uses the same schematic and similar …

Protein-tyrosine kinases p56 Lck, SYK, and ZAP-70 and downstream adaptors LAT and SLP-
76 have been implicated as essential components in T-cell activation. Another lymphoid …

The protein tyrosine kinase ZAP-70 plays a central role in T-cell activation. Following
receptor engagement, ZAP-70 is recruited to the phosphorylated subunits of the T-cell …

Triggering of mast cells and basophils by IgE and Ag initiates a cascade of biochemical
events that lead to cell degranulation and the release of allergic mediators. Receptor …

Src family kinases are suppressed by a" tail bite" mechanism, in which the binding of a
phosphorylated tyrosine in the C terminus of the protein to the Src homology (SH) 2 domain …

T cell-specific adapter (TSAd) protein and adapter protein in lymphocytes of unknown
function (ALX) are two related Src homology 2 (SH2) domain-containing signaling adapter …