Alternative polyadenylation generates numerous 3′ mRNA isoforms that can differ in their
stability, structure, and function. These isoforms can be used to map mRNA stabilizing and …

The 3′ ends of eukaryotic mRNAs are generated by cleavage of nascent transcripts
followed by polyadenylation, which occurs at numerous sites within 3′ untranslated regions …

We measured half-lives of 21,248 mRNA 3′ isoforms in yeast by rapidly depleting RNA
polymerase II from the nucleus and performing direct RNA sequencing throughout the decay …

Differences in the decay rates of individual mRNAs can have profound effects on the overall
levels of expression of specific genes. Although the potential importance of mRNA stability …

Messenger RNA stability in yeast Page 1 YEAST VOL. 5: 239-257 (1989) Messenger RNA
Stability in Yeast ALISTAIR JP BROWN Biotechnology Unit, Institute of Genetics, University …

A general pathway of mRNA turnover has been described for yeast in which the 3′ poly (A)
tail is first deadenylated to an oligo (A) length, leading to decapping and subsequent 5 …

A large set of yeast mRNA 3′-processing regulatory sequences was analyzed statistically,
revealing a systematic variation that correlates with measured mRNA stability. Transcripts …

In Saccharomyces cerevisiae, previous measurements of mRNA stabilities have been
determined on a per-gene basis. We and others have recently shown that yeast genes give …

Cells have compensatory mechanisms to coordinate the rates of major biological processes,
thereby permitting growth in a wide variety of conditions. Here, we uncover a compensatory …

To determine pathways of mRNA turnover in yeast, we have followed the poly (A) tail
removal and degradation of a pulse of newly synthesized transcripts from four different …