[HTML][HTML] Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2
H Takeshima, S Komazaki, K Hirose, M Nishi… - The EMBO …, 1998 - embopress.org
The ryanodine receptor type 2 (RyR‐2) functions as a Ca 2+‐induced Ca 2+ release (CICR)
channel on intracellular Ca 2+ stores and is distributed in most excitable cells with the …
channel on intracellular Ca 2+ stores and is distributed in most excitable cells with the …
[HTML][HTML] Generation and characterization of mutant mice lacking ryanodine receptor type 3
H Takeshima, T Ikemoto, M Nishi, N Nishiyama… - Journal of Biological …, 1996 - ASBMB
The ryanodine receptor type 3 (RyR-3) functions as a Ca 2+-induced Ca 2+ release (CICR)
channel and is distributed in a wide variety of cell types including skeletal muscle and …
channel and is distributed in a wide variety of cell types including skeletal muscle and …
Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors
T Ikemoto, S Komazaki, H Takeshima… - The Journal of …, 1997 - Wiley Online Library
1 We generated mice with targeted disruptions in the genes for both ryanodine receptor type
1 (RyR‐1) and type 3 (RyR‐3) to study the functional roles of RyR subtypes in skeletal …
1 (RyR‐1) and type 3 (RyR‐3) to study the functional roles of RyR subtypes in skeletal …
Molecular Basis of Ca2+ Activation of the Mouse Cardiac Ca2+ Release Channel (Ryanodine Receptor)
P Li, SRW Chen - The Journal of general physiology, 2001 - rupress.org
Activation of the cardiac ryanodine receptor (RyR2) by Ca2+ is an essential step in
excitation-contraction coupling in heart muscle. However, little is known about the molecular …
excitation-contraction coupling in heart muscle. However, little is known about the molecular …
Alternative Splicing of Ryanodine Receptors Modulates Cardiomyocyte Ca2+ Signaling and Susceptibility to Apoptosis
CH George, SA Rogers, BMA Bertrand… - Circulation …, 2007 - Am Heart Assoc
Ca2+ release via type 2 ryanodine receptors (RyR2) regulates cardiac function. Molecular
cloning of human RyR2 identified 2 alternatively spliced variants, comprising 30-and 24-bp …
cloning of human RyR2 identified 2 alternatively spliced variants, comprising 30-and 24-bp …
RyR2 mutations linked to ventricular tachycardia and sudden death reduce the threshold for store-overload-induced Ca2+ release (SOICR)
D Jiang, B Xiao, D Yang, R Wang… - Proceedings of the …, 2004 - National Acad Sciences
The cardiac ryanodine receptor (RyR2) governs the release of Ca2+ from the sarcoplasmic
reticulum, which initiates muscle contraction. Mutations in RyR2 have been linked to …
reticulum, which initiates muscle contraction. Mutations in RyR2 have been linked to …
Ryanodine receptor channelopathies
NA Benkusky, EF Farrell, HH Valdivia - Biochemical and biophysical …, 2004 - Elsevier
Ryanodine receptors (RyR) are the Ca2+ release channels of sarcoplasmic reticulum that
provide the majority of the [Ca2+] necessary to induce contraction of cardiac and skeletal …
provide the majority of the [Ca2+] necessary to induce contraction of cardiac and skeletal …
[HTML][HTML] Ryanodine receptor studies using genetically engineered mice
A Kushnir, MJ Betzenhauser, AR Marks - FEBS letters, 2010 - Elsevier
Ryanodine receptors (RyR) regulate intracellular Ca2+ release in many cell types and have
been implicated in a number of inherited human diseases. Over the past 15years genetically …
been implicated in a number of inherited human diseases. Over the past 15years genetically …
Ca (2+)‐induced Ca2+ release in myocytes from dyspedic mice lacking the type‐1 ryanodine receptor.
H Takeshima, T Yamazawa, T Ikemoto… - The EMBO …, 1995 - embopress.org
While subtypes 1 and 2 of the ryanodine receptor (RyR) function as intracellular Ca2+
release channels, little is known about the function of the third subtype (RyR‐3), first …
release channels, little is known about the function of the third subtype (RyR‐3), first …
An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line
E Zvaritch, F Depreux, N Kraeva… - Proceedings of the …, 2007 - National Acad Sciences
A heterozygous Ile4898 to Thr (I4898T) mutation in the human type 1 ryanodine
receptor/Ca2+ release channel (RyR1) leads to a severe form of central core disease. We …
receptor/Ca2+ release channel (RyR1) leads to a severe form of central core disease. We …