Background Weight loss is recommended for overweight or obese patients with type 2
diabetes on the basis of short-term studies, but long-term effects on cardiovascular disease …

Overweight and obesity are major contributors to both type 2 diabetes and cardiovascular
disease (CVD). Moreover, individuals with type 2 diabetes who are overweight or obese are …

Objective We evaluated long-term impact of sustained weight loss versus weight regain on
cardiovascular risk factors in real-world clinical practice. Methods We evaluated 129 obese …

OBJECTIVE—The effectiveness of intentional weight loss in reducing cardiovascular
disease (CVD) events in type 2 diabetes is unknown. This report describes 1-year changes …

Background Lifestyle interventions produce short-term improvements in glycemia and
cardiovascular disease (CVD) risk factors in individuals with type 2 diabetes mellitus, but no …

Given the array of adverse health consequences of obesity, including increased risk for type
2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), the Look AHEAD trial (N …

OBJECTIVE Short-term weight loss improves cardiovascular disease (CVD) risk factors. We
sought to determine the longer-term effects of maintaining weight loss or, conversely …

Objective. The Look AHEAD (Action for Health in Diabetes) study is a 16-centre randomised
clinical trial in overweight and obese individuals with type 2 diabetes, designed to evaluate …

There is strong and consistent evidence that obesity management can delay progression
from prediabetes to type 2 diabetes (1, 2) and may be beneficial in the treatment of type 2 …

Objective To evaluate 8‐year weight losses achieved with intensive lifestyle intervention (ILI)
in the Look AHEAD (Action for Health in Diabetes) study. Design and Methods Look AHEAD …