The design and profile of a series of indole containing long acting β2-adrenoceptor agonists
is described. Evaluation of these analogues using an in vitro guinea pig trachea tissue …

A multivalent approach was applied to the design of long-acting inhaled β2-adrenoceptor
agonists. A series of dimeric arylethanolamines based on the short acting β2-adrenoceptor …

Publisher Summary Long acting β 2-adrenoceptor agonists are a highly precedented drug
class used for the treatment of asthma and chronic obstructive pulmonary disease (COPD) …

Inhaled long-acting β2-adrenoceptor agonists (LABAs) are highly effective bronchodilators
in the treatment of asthma and chronic obstructive pulmonary disease. There is significant …

Following a lipophilicity-based hypothesis, an 8-hydroxyquinolinone 2-aminoindan derived
series of β2-adrenoceptor agonists have been prepared and evaluated for their potential as …

The current mainstay of asthma treatment relies on two distinct categories of drugs,
bronchodilators, of which the most potent are thefl-adrenoceptor agonists, and anti …

A multivalent approach focused on amine-based secondary binding groups was applied to
the discovery of long-acting inhaled β 2-agonists. Addition of amine moieties to the neutral …

A novel series of potent and selective sulfonamide derived β2-adrenoreceptor agonists are
described that exhibit potential as inhaled ultra-long-acting bronchodilators for the treatment …

After the discovery of formoterol and salmeterol, new candidates for long-acting β2-
adrenoceptor agonists (LABAs) have emerged from various companies. In particular, once …

β2-Adrenoceptor agonists with basic and acidic groups attached via an alkyl linker to the
phenyl ethanolamine core were prepared and investigated in vitro and in vivo. The …