Background The inflammation and oxidative stress (OS) have been considered crucial
components of the pathogenesis of depression. Edaravone (EDA), a free radical scavenger …

Backgrounds: Abundant reports indicate that neuroinflammatory signaling contributes to
behavioral complications associated with depression and may be related to treatment …

Background Selective serotonin reuptaker inhibitors, including fluoxetine, are widely studied
and prescribed antidepressants, while their exact molecular and cellular mechanism are yet …

The present study was performed to investigate the antidepressant effect of echinacoside
(ECH) using chronic unpredictable mild stress (CUMS) induced depression mice and …

Depression is an overwhelming health concern, and many patients fail to optimally respond
to available standard therapies. Neuroplasticity and blood–brain barrier (BBB) integrity are …

Clinical evidence indicated that eicosapentaenoic acid (EPA) was more effective than
docosahexaenoic acid (DHA) in depression treatment. However, possible mechanisms …

Abstract Inhibition of phosphodiesterase-4 (PDE4) produces robust anti-inflammatory and
antidepressant-like effects in multiple animal models. However, the detailed mechanisms …

Aims Erythropoietin (EPO) is a glycoprotein cytokine that exerts therapeutic potential on
neurological disorders by promoting neurogenesis and angiogenesis. However, its role as …

Esculetin is one of the major bioactive compounds of Cichorium intybus L. The main
purpose of the present study was to investigate the effects and possible underlying …

Rationale A complex relationship exists among stressful situations, body's reaction to stress,
and the onset of clinical depression. Chronic unpredictable stressors can produce a …