While classical cannabinoid receptors are known to crucially impact on myocardial infarction
(MI) repair, a function of the cannabinoid-sensitive receptor GPR55 herein is poorly …

Background The activation of G protein-coupled receptors (GPCR) signaling by external
stimuli has been implicated in inducing cardiac stress and stress responses. GPR22 is an …

Endocannabinoids modulate atherogenesis by triggering different receptors. Recently,
orphan G protein-coupled receptors (GPRs) were suggested to be activated by …

G protein coupled receptor 55 (GPR55) is expressed throughout the body, and although its
exact physiological function is unknown, studies have suggested a role in the cardiovascular …

Endocannabinoids are increasingly being recognized as key lipid-derived regulators of
immune function [1]. Although the peripheral cannabinoid type 2 receptor (CB2) is thought to …

Diabetes is the ninth leading cause of death, with an estimated 1.5 million deaths worldwide.
Type 2 diabetes (T2D) results from the body's ineffective use of insulin and is largely the …

Hypertrophic growth of the cardiomyocytes is one of the core mechanisms underlying
cardiac hypertrophy. However, the mechanism underlying cardiac hypertrophy remains not …

Rationale: Restoration of coronary artery blood flow is the most effective means of
ameliorating myocardial damage triggered by ischemic heart disease. However, coronary …

Myocardial infarction (MI) is a lethal disease that causes irreversible cardiomyocyte death
and subsequent cardiovascular remodeling. We have previously shown that the …

G-protein-coupled receptor-35 (GPR35) has been identified as a receptor for the tryptophan
metabolite kynurenic acid (KynA) and suggested to modulate macrophage polarization in …