[PDF][PDF] Targeting hepatocytes via the asialoglycoprotein-receptor

D Stokmaier - 2010 - edoc.unibas.ch
The asialoglycoprotein-receptor (ASGP-R) is a C-type lectin predominantly expressed on
the sinusoidal surface of mammalian hepatocytes and is responsible for the blood-clearance …

[PDF][PDF] Design and synthesis of high affinity ligands for the asialoglycoprotein receptor (ASGP-R)

O Khorev - 2007 - edoc.unibas.ch
The asialoglycoprotein receptor (ASGP-R) is a carbohydrate-binding protein from the C-type
lectin family that is expressed exclusively and in high numbers on mammalian hepatocytes …

Linking structure and function of the asialoglycoprotein receptor H1-CRD using site-directed mutagenesis and isotope labeling

AK Johansson - 2007 - edoc.unibas.ch
The asialoglycoprotein receptor (ASGP-R) is a C-type lectin, abundantly expressed on
hepatocytes. It mediates the clearance of desialylated glycoproteins carrying terminal …

Physiological roles of asialoglycoprotein receptors (ASGPRs) variants and recent advances in hepatic-targeted delivery of therapeutic molecules via ASGPRs

J Hu, J Liu, D Yang, M Lu, J Yin - Protein and peptide letters, 2014 - ingentaconnect.com
The asialoglycoprotein receptor (ASGPR) is a high-capacity C-type lectin receptor mainly
expressed on mammalian hepatic cells. The physiological function of ASGPR has not been …

Limitations on the specificity of targeting asialoglycoprotein-drug conjugates to hepatocytes

P van der Sluijs, DK Meijer - Liver Diseases. Targeted Diagnosis …, 1991 - books.google.com
The liver can be considered as the cornerstone in the maintenance of whole-body
homeostasis. Major features of this are uptake and processing of nutrients absorbed from …

[HTML][HTML] Determination of the upper size limit for uptake and processing of ligands by the asialoglycoprotein receptor on hepatocytesin vitro and in vivo

PCN Rensen, LAJM Sliedregt, M Ferns… - Journal of biological …, 2001 - ASBMB
The asialoglycoprotein receptor (ASGPr) on hepatocytes plays a role in the clearance of
desialylated proteins from the serum. Although its sugar preference (N-acetylgalactosamine …

Benefit and application of antibodies against the H1 carbohydrate recognition domain of the human hepatic asialoglycoprotein receptor

R Born - 2005 - edoc.unibas.ch
The asialoglycoprotein receptor (ASGPR), composed of the subunits H1 and H2, is
predominantly expressed on the sinusoidal surface of mammalian hepatocytes and involved …

Well-defined multivalent ligands for hepatocytes targeting via asialoglycoprotein receptor

X Huang, JC Leroux, B Castagner - Bioconjugate chemistry, 2017 - ACS Publications
Targeted delivery of therapeutic agents to hepatocytes is a particularly attractive strategy for
the treatment of hepatocellular carcinoma and other liver diseases. The asialoglycoprotein …

Glycomimetic ligands for the human asialoglycoprotein receptor

SK Mamidyala, S Dutta, BA Chrunyk… - Journal of the …, 2012 - ACS Publications
The asialoglycoprotein receptor (ASGPR) is a high-capacity galactose-binding receptor
expressed on hepatocytes that binds its native substrates with low affinity. More potent …

Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor

O Khorev, D Stokmaier, O Schwardt, B Cutting… - Bioorganic & medicinal …, 2008 - Elsevier
A series of novel, fluorescent ligands designed to bind with high affinity and specificity to the
asialoglycoprotein receptor (ASGP-R) has been synthesized and tested on human liver …