The large intracellular pool of asialoglycoprotein receptors functions during the endocytosis of asialoglycoproteins by isolated rat hepatocytes.

PH Weigel, JA Oka - Journal of Biological Chemistry, 1983 - Elsevier
The function of intracellular asialoglycoprotein receptors during the endocytosis of asialo-
orosomucoid in isolated hepatocytes was assessed by following changes in the occupancy …

Active targeting of asiaglycoprotein receptor using sterically stabilized lipoplexes

K Naicker, M Ariatti, M Singh - European journal of lipid science …, 2016 - Wiley Online Library
The large numbers of hepatic disorders of a genetic origin continues to drive the quest for
safe and efficient non‐viral gene delivery systems with the design features suitable for in …

Ligand-induced clustering of asialoglycoprotein receptors on rat hepatocytes at 4 degrees C.

P Van Der Smissen, T Vael, PJ Courtoy… - European journal of …, 1993 - europepmc.org
The platinum-carbon replica technique was applied to rat hepatocyte monolayers to
visualize the distribution of the receptor responsible for the clearance of asialoglycoproteins …

High‐Affinity Ligand Binding to Subunit HI of the Asialoglycoprotein Receptor in the Absence of Subunit H2

MD Bider, R Cescato, P Jenö… - European journal of …, 1995 - Wiley Online Library
The hepatic asialoglycoprotein receptor is a hetero‐oligomer composed of two homologous
subunits. The specificity and affinity of ligand binding depends on the number and spatial …

Receptor-mediated endocytosis of asialoglycoproteins by rat hepatocytes: receptor-positive and receptor-negative endosomes.

SC Mueller, AL Hubbard - The Journal of cell biology, 1986 - rupress.org
We have used combinations of subcellular fractionation, specific cytochemical tracers, and
quantitative immunoadsorption to determine when, where, and in which intracellular …

[引用][C] Asialoglycoprotein receptor and its application in liver-targeted drug delivery

H Yuan-Yu, L Zi-Cai - Progress in …, 2015 - CHINESE ACAD SCIENCES, INST …

[HTML][HTML] Evaluation of GalNAc-siRNA conjugate activity in pre-clinical animal models with reduced asialoglycoprotein receptor expression

JLS Willoughby, A Chan, A Sehgal, JS Butler, JK Nair… - Molecular therapy, 2018 - cell.com
The hepatocyte-specific asialoglycoprotein receptor (ASGPR) is an ideal candidate for
targeted drug delivery to the liver due to its high capacity for substrate clearance from …

Composition, antigenic properties and hepatocyte surface expression of the woodchuck asialoglycoprotein receptor

J Diao, TI Michalak - Journal of Receptors and Signal Transduction, 1996 - Taylor & Francis
We have purified woodchuck hepatic asialoglycoprotein receptor (ASGPR) by ligand affinity
chromatography and have identified it as a heterooligomeric complex comprised of two …

[HTML][HTML] Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit: its obligate requirement for the stable expression of oligomeric receptor

R Tozawa, S Ishibashi, J Osuga, K Yamamoto… - Journal of Biological …, 2001 - ASBMB
The asialoglycoprotein receptor is an abundant hetero-oligomeric endocytic receptor that is
predominantly expressed on the sinusoidal surface of the hepatocytes. A number of …

Identification of novel small-molecule ASGP-R ligands

AG Majouga, YA Ivanenkov, MS Veselov… - Current Drug …, 2016 - ingentaconnect.com
During the past decade asialoglycoprotein receptor (ASGP-R) expressed predominantly by
hepatocytes has attracted a considerable attention as a convenient biomolecular trap for …