The large intracellular pool of asialoglycoprotein receptors functions during the endocytosis of asialoglycoproteins by isolated rat hepatocytes.
PH Weigel, JA Oka - Journal of Biological Chemistry, 1983 - Elsevier
The function of intracellular asialoglycoprotein receptors during the endocytosis of asialo-
orosomucoid in isolated hepatocytes was assessed by following changes in the occupancy …
orosomucoid in isolated hepatocytes was assessed by following changes in the occupancy …
Active targeting of asiaglycoprotein receptor using sterically stabilized lipoplexes
The large numbers of hepatic disorders of a genetic origin continues to drive the quest for
safe and efficient non‐viral gene delivery systems with the design features suitable for in …
safe and efficient non‐viral gene delivery systems with the design features suitable for in …
Ligand-induced clustering of asialoglycoprotein receptors on rat hepatocytes at 4 degrees C.
P Van Der Smissen, T Vael, PJ Courtoy… - European journal of …, 1993 - europepmc.org
The platinum-carbon replica technique was applied to rat hepatocyte monolayers to
visualize the distribution of the receptor responsible for the clearance of asialoglycoproteins …
visualize the distribution of the receptor responsible for the clearance of asialoglycoproteins …
High‐Affinity Ligand Binding to Subunit HI of the Asialoglycoprotein Receptor in the Absence of Subunit H2
MD Bider, R Cescato, P Jenö… - European journal of …, 1995 - Wiley Online Library
The hepatic asialoglycoprotein receptor is a hetero‐oligomer composed of two homologous
subunits. The specificity and affinity of ligand binding depends on the number and spatial …
subunits. The specificity and affinity of ligand binding depends on the number and spatial …
Receptor-mediated endocytosis of asialoglycoproteins by rat hepatocytes: receptor-positive and receptor-negative endosomes.
SC Mueller, AL Hubbard - The Journal of cell biology, 1986 - rupress.org
We have used combinations of subcellular fractionation, specific cytochemical tracers, and
quantitative immunoadsorption to determine when, where, and in which intracellular …
quantitative immunoadsorption to determine when, where, and in which intracellular …
[HTML][HTML] Evaluation of GalNAc-siRNA conjugate activity in pre-clinical animal models with reduced asialoglycoprotein receptor expression
JLS Willoughby, A Chan, A Sehgal, JS Butler, JK Nair… - Molecular therapy, 2018 - cell.com
The hepatocyte-specific asialoglycoprotein receptor (ASGPR) is an ideal candidate for
targeted drug delivery to the liver due to its high capacity for substrate clearance from …
targeted drug delivery to the liver due to its high capacity for substrate clearance from …
Composition, antigenic properties and hepatocyte surface expression of the woodchuck asialoglycoprotein receptor
J Diao, TI Michalak - Journal of Receptors and Signal Transduction, 1996 - Taylor & Francis
We have purified woodchuck hepatic asialoglycoprotein receptor (ASGPR) by ligand affinity
chromatography and have identified it as a heterooligomeric complex comprised of two …
chromatography and have identified it as a heterooligomeric complex comprised of two …
[HTML][HTML] Asialoglycoprotein receptor deficiency in mice lacking the major receptor subunit: its obligate requirement for the stable expression of oligomeric receptor
R Tozawa, S Ishibashi, J Osuga, K Yamamoto… - Journal of Biological …, 2001 - ASBMB
The asialoglycoprotein receptor is an abundant hetero-oligomeric endocytic receptor that is
predominantly expressed on the sinusoidal surface of the hepatocytes. A number of …
predominantly expressed on the sinusoidal surface of the hepatocytes. A number of …
Identification of novel small-molecule ASGP-R ligands
AG Majouga, YA Ivanenkov, MS Veselov… - Current Drug …, 2016 - ingentaconnect.com
During the past decade asialoglycoprotein receptor (ASGP-R) expressed predominantly by
hepatocytes has attracted a considerable attention as a convenient biomolecular trap for …
hepatocytes has attracted a considerable attention as a convenient biomolecular trap for …