Nanogels for intracellular delivery of biotherapeutics

D Li, CF van Nostrum, E Mastrobattista… - Journal of Controlled …, 2017 - Elsevier
Many biomolecules, such as proteins and genes, are presently used as therapeutics.
However, their delivery to target sites inside cells is challenging because of their large …

Nanogels as drug-delivery systems: A comprehensive overview

M Suhail, JM Rosenholm, MU Minhas… - Therapeutic …, 2019 - Taylor & Francis
Nanogels have attracted considerable attention as nanoscopic drug carriers, particularly for
site-specific or time-controlled delivery of bioactive mediators. A high diversity of polymer …

Self-assembled cationic nanogels for intracellular protein delivery

H Ayame, N Morimoto, K Akiyoshi - Bioconjugate chemistry, 2008 - ACS Publications
An effective intracellular protein delivery system with self-assembled cationic nanogels is
reported. Interaction of proteins with self-assembled nanogels of cationic cholesteryl group …

Stimulus-responsive polymeric nanogels as smart drug delivery systems

S Hajebi, N Rabiee, M Bagherzadeh, S Ahmadi… - Acta biomaterialia, 2019 - Elsevier
Nanogels are three-dimensional nanoscale networks formed by physically or chemically
cross-linking polymers. Nanogels have been explored as drug delivery systems due to their …

Nanogel functionalization: a versatile approach to meet the challenges of drug and gene delivery

E Mauri, G Perale, F Rossi - ACS Applied Nano Materials, 2018 - ACS Publications
The design of nanostructures carrying therapeutic molecules represents the new frontier in
the biological and medical fields. In particular, researchers have identified nanogels as …

[HTML][HTML] Nanogel: A versatile nano-delivery system for biomedical applications

Y Yin, B Hu, X Yuan, L Cai, H Gao, Q Yang - Pharmaceutics, 2020 - mdpi.com
Nanogel-based nanoplatforms have become a tremendously promising system of drug
delivery. Nanogels constructed by chemical crosslinking or physical self-assembly exhibit …

Polymer nanogels: a versatile nanoscopic drug delivery platform

RT Chacko, J Ventura, J Zhuang… - Advanced drug delivery …, 2012 - Elsevier
In this review we put the spotlight on crosslinked polymer nanogels, a promising platform
that has the characteristics of an “ideal” drug delivery vehicle. Some of the key aspects of …

[PDF][PDF] Polymeric nanogels as drug delivery systems.

J Kousalová, T Etrych - Physiological research, 2018 - biomed.cas.cz
The present review focuses on the description of the design, synthesis and physico-
chemical and biological evaluation of polymer nanogels. Nanogels are robust swollen cross …

Recent progress of polymeric nanogels for gene delivery

R Kandil, OM Merkel - Current opinion in colloid & interface science, 2019 - Elsevier
With its nearly unrestricted possibilities, gene therapy attracts more and more significance in
modern-day research. The only issue still seeming to hold back its clinical success is the …

Biopolymer-based nanogel approach in drug delivery: basic concept and current developments

E Altuntaş, B Özkan, S Güngör, Y Özsoy - Pharmaceutics, 2023 - mdpi.com
Due to their increased surface area, extent of swelling and active substance-loading
capacity and flexibility, nanogels made from natural and synthetic polymers have gained …