High-density lipoproteins (HDLs) have been well established to protect against the
development of atherosclerotic cardiovascular disease. It has become apparent that in …

Despite great progress being made during the last two decades in cardiovascular disease
prevention, especially by lowering low-density lipoprotein-cholesterol with statins …

There are several potential mechanisms by which HDLs protect against the development of
vascular disease. One relates to the unique ability of these lipoproteins to remove …

The development of atherosclerosis is a complex process whose central elements include
the entrapment of low-density lipoprotein in the vessel wall, its subsequent oxidative …

The formation of the atherosclerotic plaque that is characterized by the accumulation of
abnormal amounts of cholesterol-loaded macrophages in the artery wall is mediated by both …

The association of low levels of high-density lipoprotein cholesterol (HDL-C) with an
increased incidence of cardiovascular events implies a central involvement of high-density …

Accumulation of cholesterol by macrophages, leading to their transformation into foam cells
is a key event in the initiation of atherosclerosis. As maintenance of cholesterol homeostasis …

Observational studies provide overwhelming evidence that a low high-density lipoprotein
(HDL)–cholesterol level increases the risk of coronary events, both in healthy subjects and …

High-density lipoprotein (HDL) is classified as a negative risk factor due to the inverse
relationship between elevated levels of HDL cholesterol and atherosclerosis. The …

High-density lipoprotein (HDL) is well established as a negative risk factor for the
development of atherosclerosis. Epidemiologic, pathologic, and experimental studies have …