Pathogenic mechanisms underlying idiopathic pulmonary fibrosis

BJ Moss, SW Ryter, IO Rosas - Annual Review of Pathology …, 2022 - annualreviews.org
The pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell
types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in …

Epithelial injury and dysfunction in the pathogenesis of idiopathic PulmonaryFibrosis

NI Winters, A Burman, JA Kropski… - The American journal of the …, 2019 - Elsevier
Idiopathic pulmonary fibrosis is a disease of older adults leading to progressive dyspnea
and reduced exercise capacity, typically resulting in death within 3-5years of diagnosis …

Idiopathic pulmonary fibrosis: a disorder of epithelial cell dysfunction

DF Zoz, WE Lawson, TS Blackwell - The American journal of the medical …, 2011 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive dyspnea, interstitial
infiltrates in lung parenchyma and restriction on pulmonary function testing. IPF is the most …

Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis

A Günther, M Korfei, P Mahavadi… - European …, 2012 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition, with a median survival of<
3 yrs. The pathophysiology is not fully understood, but chronic injury of alveolar epithelial …

The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis

M Selman, A Pardo - Cellular signalling, 2020 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and devastating interstitial
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …

Pathogenesis of idiopathic pulmonary fibrosis

PJ Wolters, HR Collard, KD Jones - Annual Review of Pathology …, 2014 - annualreviews.org
Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease associated with
aging that is characterized by the histopathological pattern of usual interstitial pneumonia …

Developmental pathways in the pathogenesis of lung fibrosis

D Chanda, E Otoupalova, SR Smith, T Volckaert… - Molecular aspects of …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a progressive and terminal lung disease with no known
cure. IPF is a disease of aging, with median age of diagnosis over 65 years. Median survival …

Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis

THG Phan, P Paliogiannis, GK Nasrallah… - Cellular and Molecular …, 2021 - Springer
Idiopathic pulmonary fibrosis (IPF), the most common form of idiopathic interstitial
pneumonia, is a progressive, irreversible, and typically lethal disease characterized by an …

Emerging roles of airway epithelial cells in idiopathic pulmonary fibrosis

A Chakraborty, M Mastalerz, M Ansari, HB Schiller… - Cells, 2022 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is a fatal disease with incompletely understood aetiology
and limited treatment options. Traditionally, IPF was believed to be mainly caused by …

Mechanisms of pulmonary fibrosis

VJ Thannickal, GB Toews, ES White… - Annu. Rev …, 2004 - annualreviews.org
Tissue injury evokes highly conserved, tightly regulated inflammatory responses and less
well-understood host repair responses. Both inflammation and repair involve the …