Our previous studies demonstrated that exposure to hypoxia increases pulmonary artery
pressure and plasma endothelin-1 (ET-1) levels and selectively enhances ET-1 gene …

To test the hypothesis that endothelin (ET)-1 synthesis and ET receptor levels are increased
selectively in the lung of rats with chronic hypoxic pulmonary hypertension, the current study …

To clarify the roles of two different endothelin (ET) receptors in the pulmonary vasculature,
the localization and distribution of endothelin-A (ETA) and ETB receptors were investigated …

The current study tested the hypothesis that exposure to hypoxia enhances endothelin-1 (ET-
1) gene expression and elevates circulating ET-1 levels in the rat. Rats were exposed to …

Exposure to hypoxia is associated with increased pulmonary artery pressure and plasma
endothelin-1 (ET-1) levels and with selective enhancement in ET-1 peptide and mRNA and …

Biochemical and molecular biological evidence indicates that endothelin (ET)-1 and its
receptors are selectively upregulated in the lung during exposure to hypoxia, while …

Mechanisms by which endothelin (ET)-1 mediates chronic pulmonary hypertension remain
incompletely understood. Although activation of the ET type A (ETA) receptor causes …

Endothelin (ET)-1 contributes to the regulation of pulmonary vascular tone by stimulation of
the ETA and ETB receptors. Although activation of the ETA receptor causes vasoconstriction …

Endothelin-1 (ET-1) is a 21-amino acid peptide synthesized by several cell types in the lung.
Locally, ET-1 regulates vascular and airway tone and is mitogenic for vascular and airway …

Receptors for endothelin (ET)-1, a potent vasoconstrictor peptide, have two isoforms, ie ETa
receptors and ETb receptors. We previously reported that an ETa receptor antagonist greatly …