Vascular smooth muscle cell (VSMC) proliferation is a critical event in the development and
progression of vascular diseases, including atherosclerosis. We investigated whether the …

Objective—Castration of male apolipoprotein E–deficient (apoE−/−) mice reduces
angiotensin II (Ang II)–induced abdominal aorta aneurysms (AAAs) to that of female mice …

Rationale: AMP-activated protein kinase (AMPK) has been reported to play a protective role
in atherosclerosis. However, whether AMPKα2 controls atherosclerotic plaque stability …

Abdominal aortic aneurysm (AAA) rupture is estimated to cause 200,000 deaths each year.
Currently, the only treatment for AAA is surgical repair; however, this is only indicated for …

Accumulating evidence suggests that AMP-activated protein kinase (AMPK) activation exerts
anti-apoptotic effects in multiple types of cells. However, the underlying mechanisms remain …

Background—AMP-activated protein kinase (AMPK) is a stress-activated protein kinase that
works as a metabolic sensor of cellular ATP levels. Here, we investigated whether AMPK …

SUMMARY 1 AMP‐activated protein kinase (AMPK) is a serine/threonine protein kinase
involved in the regulation of cellular and organismal metabolism. AMPK has a heterotrimeric …

Rationale: The thoracic aortic wall can degenerate over time with catastrophic
consequences. Vascular smooth muscle cells (SMCs) can resist and repair artery damage …

It has recently been recognized that adiponectin protects the vasculature and prevents
atherosclerotic change through AMP-activated protein kinase (AMPK) activation, and some …

The AMP-activated protein kinase (AMPK) is a key regulator of cellular and whole-body
energy homeostasis, which acts to restore energy homoeostasis whenever cellular energy …