Objective Pregnancy-associated plasma protein-A2 (PAPP-A2) is a metalloproteinase that
cleaves IGFBP-3 and IGFBP-5. Human mutations in PAPPA2 result in short stature with a …

Bioactive free IGF-I is critically important for growth. The bioavailability of IGF-I is modulated
by the IGF-binding proteins (IGFBPs) and their proteases, such as pregnancy-associated …

Context Pregnancy-associated plasma protein A2 (PAPPA2) is a protease that cleaves IGF-
binding protein (IGFBP)-3 and IGFBP-5, liberating free IGF-I. Five patients from two families …

Background Prepubertal children with obesity frequently have enhanced growth,
accelerated skeletal maturation, and changes in the growth hormone–insulin-like growth …

Mutations in multiple genes of the growth hormone/IGF‐I axis have been identified in
syndromes marked by growth failure. However, no pathogenic human mutations have been …

The pappalysins pregnancy associated plasma protein-A (PAPP-A) and-A2 (PAPP-A2) act
as proteinases of insulin-like growth factor-1 (IGF-1) binding proteins, while stanniocalcin-2 …

Context: Pregnancy-associated plasma protein-A2 (PAPP-A2) is a metalloproteinase that
specifically cleaves IGFBP-3 and IGFBP-5. Mutations in the PAPP-A2 gene have recently …

Objective Insulin-like growth factor binding proteins (IGFBPs) are involved in glucose and
lipid metabolism, and their actions are modulated by proteases. The aim of this study was to …

Firstly discovered as a placental protein present abundantly in the circulation of pregnant
women, pregnancy-associated plasma protein-A (PAPP-A) is widely expressed in multiple …

Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a
placental protein of unknown function, present at high concentrations in the circulation of …