Solid-phase microextraction and the human fecal VOC metabolome

E Dixon, C Clubb, S Pittman, L Ammann, Z Rasheed… - PloS one, 2011 - journals.plos.org
The diagnostic potential and health implications of volatile organic compounds (VOCs)
present in human feces has begun to receive considerable attention. Headspace solid …

[PDF][PDF] Optimisation of sample preparation for direct SPME-GC-MS analysis of murine and human faecal volatile organic compounds for metabolomic studies

S Reade, A Mayor, R Aggio, T Khalid… - J Anal Bioanal …, 2014 - researchgate.net
The analysis of volatile organic compounds (VOCs) emitted from biological fluids such as
blood, urine, breath and faeces, has been receiving more attention from researchers and …

The approach to sample acquisition and its impact on the derived human fecal microbiome and VOC metabolome

RD Couch, K Navarro, M Sikaroodi, P Gillevet… - PloS one, 2013 - journals.plos.org
Recent studies have illustrated the importance of the microbiota in maintaining a healthy
state, as well as promoting disease states. The intestinal microbiota exerts its effects …

Methods to detect volatile organic compounds for breath biopsy using solid-phase microextraction and gas chromatography–mass spectrometry

E Schulz, M Woollam, P Grocki, MD Davis, M Agarwal - Molecules, 2023 - mdpi.com
Volatile organic compounds (VOCs) are byproducts from metabolic pathways that can be
detected in exhaled breath and have been reported as biomarkers for different diseases …

Comparison of fecal collection methods on variation in gut metagenomics and untargeted metabolomics

H Guan, Y Pu, C Liu, T Lou, S Tan, M Kong, Z Sun… - Msphere, 2021 - Am Soc Microbiol
Integrative analysis of high-quality metagenomics and metabolomics data from fecal
samples provides novel clues for the mechanism underpinning gut microbe-human …

Freeze-drying: an alternative method for the analysis of volatile organic compounds in the headspace of urine samples using solid phase micro-extraction coupled to …

RBM Aggio, A Mayor, S Coyle, S Reade… - Chemistry Central …, 2016 - Springer
Abstract Background Volatile organic compounds (VOCs) can be intermediates of metabolic
pathways and their levels in biological samples may provide a better understanding about …

A comparison of sample preparation methods for extracting volatile organic compounds (VOCs) from equine faeces using HS-SPME

R Hough, D Archer, C Probert - Metabolomics, 2018 - Springer
Introduction Disturbance to the hindgut microbiota can be detrimental to equine health.
Metabolomics provides a robust approach to studying the functional aspect of hindgut …

Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene• GUT Fecal Stabilization

H Isokääntä, L Pinto da Silva, N Karu… - Analytical …, 2024 - ACS Publications
Metabolites from feces provide important insights into the functionality of the gut microbiome.
As immediate freezing is not always feasible in gut microbiome studies, there is a need for …

An LC-QToF MS based method for untargeted metabolomics of human fecal samples

K Cheng, C Brunius, R Fristedt, R Landberg - Metabolomics, 2020 - Springer
Introduction Consensus in sample preparation for untargeted human fecal metabolomics is
lacking. Objectives To obtain sample preparation with broad metabolite coverage for high …

Impact of sample storage on the NMR fecal water metabolome

V O'Sullivan, F Madrid-Gambin, T Alegra, H Gibbons… - ACS …, 2018 - ACS Publications
The study of the fecal metabolome is an important area of research to better understand the
human gut microbiome and its impact on human health and diseases. However, there is a …