FTO promotes SREBP1c maturation and enhances CIDEC transcription during lipid accumulation in HepG2 cells
A Chen, X Chen, S Cheng, L Shu, M Yan, L Yao… - … et Biophysica Acta (BBA …, 2018 - Elsevier
The fat mass and obesity-associated (FTO) gene is tightly related to body weight and fat
mass, and plays a pivotal role in regulating lipid accumulation in hepatocytes. However, the …
mass, and plays a pivotal role in regulating lipid accumulation in hepatocytes. However, the …
Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m6A methylation and increasing the stability of SREBF1 and ChREBP mRNAs
Z Tang, C Sun, Y Yan, Z Niu, Y Li, X Xu… - Journal of Molecular …, 2022 - academic.oup.com
Previous studies have indicated an association of fat mass and obesity-associated (FTO)
with nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease …
with nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease …
[HTML][HTML] SREBP-1-independent regulation of lipogenic gene expression in adipocytes
M Sekiya, N Yahagi, T Matsuzaka, Y Takeuchi… - Journal of lipid …, 2007 - ASBMB
Sterol regulatory element-binding protein (SREBP)-1c is now well established as a key
transcription factor for the regulation of lipogenic enzyme genes such as FAS in hepatocytes …
transcription factor for the regulation of lipogenic enzyme genes such as FAS in hepatocytes …
[HTML][HTML] Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass
B Knebel, J Haas, S Hartwig, S Jacob, C Köllmer… - PloS one, 2012 - journals.plos.org
The pathogenesis of fatty liver is not understood in detail, but lipid overflow as well as de
novo lipogenesis (DNL) seem to be the key points of hepatocyte accumulation of lipids. One …
novo lipogenesis (DNL) seem to be the key points of hepatocyte accumulation of lipids. One …
FMO2 ameliorates nonalcoholic fatty liver disease by suppressing ER-to-Golgi transport of SREBP1
C Ke, C Xiao, J Li, X Wu, Y Zhang, Y Chen, S Sheng… - Hepatology, 2023 - journals.lww.com
Conclusion: In hepatocytes, FMO2 is a novel molecule that protects against the progression
of NAFL/NASH independent of enzyme activity. FMO2 impairs lipogenesis in HFD or …
of NAFL/NASH independent of enzyme activity. FMO2 impairs lipogenesis in HFD or …
[HTML][HTML] FoxO3 regulates hepatic triglyceride metabolism via modulation of the expression of sterol regulatory-element binding protein 1c
Background Excessive intrahepatic lipid accumulation is the major characteristic of
nonalcoholic fatty liver disease (NAFLD). We sought to identify the mechanisms involved in …
nonalcoholic fatty liver disease (NAFLD). We sought to identify the mechanisms involved in …
[HTML][HTML] Transient hepatic overexpression of insulin-like growth factor 2 induces free cholesterol and lipid droplet formation
SM Kessler, S Laggai, E Van Wonterghem… - Frontiers in …, 2016 - frontiersin.org
Although insulin-like growth factor 2 (IGF2) has been reported to be overexpressed in
steatosis and steatohepatitis, a causal role of IGF2 in steatosis development remains …
steatosis and steatohepatitis, a causal role of IGF2 in steatosis development remains …
[PDF][PDF] Cidea promotes hepatic steatosis by sensing dietary fatty acids
High levels of dietary saturated fat have been closely associated with the development of
hepatic steatosis, but the factors that mediate this process remain elusive. Here, we …
hepatic steatosis, but the factors that mediate this process remain elusive. Here, we …
The regulation of TFEB in lipid homeostasis of non-alcoholic fatty liver disease: Molecular mechanism and promising therapeutic targets
S Yu, Z Wang, L Ding, L Yang - Life sciences, 2020 - Elsevier
Nonalcoholic fatty liver disease (NAFLD), which is characterized by disruption of lipid
homeostasis, has been the leading cause of chronic liver disease worldwide. However …
homeostasis, has been the leading cause of chronic liver disease worldwide. However …
[HTML][HTML] Fat mass and obesity–associated protein promotes liver steatosis by targeting PPARα
X Wei, J Zhang, M Tang, X Wang, N Fan… - Lipids in Health and …, 2022 - Springer
Background Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver
disease worldwide. The fat mass and obesity–associated protein (FTO) has been shown to …
disease worldwide. The fat mass and obesity–associated protein (FTO) has been shown to …