Maintenance of oxygen homoeostasis is required for the survival of higher organisms. The
transcription factor hypoxia inducible factor (HIF) has a crucial role in oxygen homoeostasis …

Decreased oxygen availability (hypoxia) promotes physiological processes such as energy
metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor …

Oxygen is required for the survival of the majority of eukaryotic organisms, as it is important
for many cellular processes. Eukaryotic cells utilize oxygen for the production of biochemical …

All eukaryotic cells utilize oxidative phosphorylation to maintain their high‐energy
phosphate stores. Mitochondrial oxygen consumption is required for ATP generation, and …

Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell
proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF) …

Significance: Cells sense and respond to a shortage of oxygen by activating the hypoxia-
inducible transcription factors HIF-1 and HIF-2 and evoking adaptive responses. Recent …

Multicellular organisms initiate adaptive responses when oxygen (O 2) availability
decreases. The underlying mechanisms of O 2 sensing remain unclear. Mitochondria have …

Multicellular organisms initiate adaptive responses when oxygen (O 2) availability
decreases, but the underlying mechanism of O 2 sensing remains elusive. We find that …

Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to
hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most …

Hypoxia induces the stabilization and transcriptional activation of the hypoxia-inducible
factor 1α (HIF-1α) protein, the regulatory member of the HIF-1 complex. The molecular …