Abstract Nucleotides, eg, adenosine‐5′‐triphosphate (ATP), can be released into the
extracellular space under acute or chronic inflammatory conditions and have been shown to …

P2Y receptors are expressed in virtually all epithelia and are responsible for the control of
fluid and electrolyte transport. In asthmatic inflammation, the bronchial epithelia are …

P2Y nucleotide receptors activated by mono-and dinucleotides have already been found in
lung tissue. Here, we compare effects of dinucleotides and mononucleotides on arachidonic …

Alveolar macrophages play a crucial role in the pathogenesis of inflammatory airway
diseases. By the generation and release of different inflammatory mediators they contribute …

ATP released in the early inflammatory processes acts as a danger signal by binding to
purinergic receptors expressed on immune cells. A major contribution of the P2Y2 receptor …

Uncontrolled inflammation is frequently observed in human respiratory diseases.
Extracellular ATP can induce a number of physiological phenomena via binding to …

A growing body of information indicates that release of intracellular nucleotides represents
an important way to modulate several cell pathways in physiological or pathological …

Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …

In addition to their well characterized and established role in haemostasis and thrombosis,
platelets contribute to the pathogenesis of inflammation. Adenine nucleotides are signalling …

P2X receptors are cation‐selective ion channels activated by extracellular ATP. They form
homo‐and heterotrimeric complexes that differ in their functional properties and subcellular …