Systems medicine: the future of medical genomics and healthcare

C Auffray, Z Chen, L Hood - Genome medicine, 2009 - Springer
High-throughput technologies for DNA sequencing and for analyses of transcriptomes,
proteomes and metabolomes have provided the foundations for deciphering the structure …

Systems biology and the future of medicine

J Loscalzo, AL Barabasi - Wiley Interdisciplinary Reviews …, 2011 - Wiley Online Library
Contemporary views of human disease are based on simple correlation between clinical
syndromes and pathological analysis dating from the late 19th century. Although this …

Systems medicine: the application of systems biology approaches for modern medical research and drug development

D Ayers, PJ Day - Molecular Biology International, 2015 - Wiley Online Library
The exponential development of highly advanced scientific and medical research
technologies throughout the past 30 years has arrived to the point where the high number of …

Systems medicine: evolution of systems biology from bench to bedside

RS Wang, BA Maron, J Loscalzo - … Reviews: Systems Biology …, 2015 - Wiley Online Library
High‐throughput experimental techniques for generating genomes, transcriptomes,
proteomes, metabolomes, and interactomes have provided unprecedented opportunities to …

Systems approaches to biology and disease enable translational systems medicine

L Hood, Q Tian - Genomics, Proteomics and Bioinformatics, 2012 - academic.oup.com
The development and application of systems strategies to biology and disease are
transforming medical research and clinical practice in an unprecedented rate. In the …

Whither systems medicine?

R Apweiler, T Beissbarth, MR Berthold… - … & molecular medicine, 2018 - nature.com
New technologies to generate, store and retrieve medical and research data are inducing a
rapid change in clinical and translational research and health care. Systems medicine is the …

Systems biology: its practice and challenges

A Aderem - Cell, 2005 - cell.com
Systems biology is a comprehensive quantitative analysis of the manner in which all the
components of a biological system interact functionally over time. Such an analysis is …

Systems biology: personalized medicine for the future?

R Chen, M Snyder - Current opinion in pharmacology, 2012 - Elsevier
Systems biology is actively transforming the field of modern health care from symptom-
based disease diagnosis and treatment to precision medicine in which patients are treated …

The art and practice of systems biology in medicine: mapping patterns of relationships

J Van der Greef, S Martin, P Juhasz… - Journal of proteome …, 2007 - ACS Publications
Systems biology has developed in recent years from a technology-driven enterprise to a
new strategic tool in Life Sciences, particularly for innovative drug discovery and drug …

Enabling multiscale modeling in systems medicine

O Wolkenhauer, C Auffray, O Brass, J Clairambault… - Genome medicine, 2014 - Springer
Systems medicine is an interdisciplinary approach that integrates data from basic research
and clinical practice to improve our understanding and treatment of diseases. Systems …