Biosynthesis and heterologous production of furanocoumarins: perspectives and current challenges

JL Rodrigues, LR Rodrigues - Natural Product Reports, 2021 - pubs.rsc.org
Covering: up to October 2020 Furanocoumarins are plant secondary metabolites used to
treat several skin disorders, such as psoriasis and vitiligo, and also with other potential …

Progress in the chemistry of naturally occurring coumarins

SD Sarker, L Nahar - Progress in the Chemistry of Organic Natural …, 2017 - Springer
Coumarins are the largest group of 1-benzopyran derivatives found in plants. The initial
member of this group of compounds, coumarin (2 H-1-benzopyran-2-one), a fragrant …

Challenges in the Heterologous Production of Furanocoumarins in Escherichia coli

JL Rodrigues, D Gomes, LR Rodrigues - Molecules, 2022 - mdpi.com
Coumarins and furanocoumarins are plant secondary metabolites with known biological
activities. As they are present in low amounts in plants, their heterologous production …

Furo [3, 2-c] coumarins carrying carbon substituents at C-2 and/or C-3. Isolation, biological activity, synthesis and reaction mechanisms

I Cortés, LJ Cala, ABJ Bracca, TS Kaufman - RSC advances, 2020 - pubs.rsc.org
The isolation, biological activity and synthesis of natural furo [3, 2-c] coumarins are
presented, covering mainly the developments in the last 35 years. The most relevant …

Botanical sources, chemistry, analysis, and biological activity of furanocoumarins of pharmaceutical interest

R Bruni, D Barreca, M Protti, V Brighenti, L Righetti… - Molecules, 2019 - mdpi.com
The aim of this work is to provide a critical review of plant furanocoumarins from different
points of view, including their chemistry and biosynthetic pathways to their extraction …

Furocoumarins in medicinal chemistry. Synthesis, natural occurrence and biological activity

L Santana, E Uriarte, F Roleira… - Current medicinal …, 2004 - ingentaconnect.com
The scope of this review encompasses the importance of furocoumarins and the most
important developments in this field that have been made in recent years, with particular …

Recent advances in the biosynthesis of coumarin and its derivatives

Y Zou, Y Teng, J Li, Y Yan - Green Chemical Engineering, 2024 - Elsevier
Coumarin and its derivatives, presenting in many organisms (plants, fungi, and bacteria), are
critical metabolites composed of fused benzene and α-pyrone rings. With unique biological …

Furanocoumarins: Biomolecules of therapeutic interest

JA Del Río, L Díaz, D García-Bernal, M Blanquer… - Studies in Natural …, 2014 - Elsevier
Furanocoumarins are a subgroup of phenolic compounds included in the coumarins group.
They can be subdivided into two types: linear, generically known as psoralens, among …

Recent advances in the synthesis and applications of furocoumarin derivatives

C Chen, ZB Tang, Z Liu - Chinese Chemical Letters, 2023 - Elsevier
Furocoumarins are an important class of heterocyclic compounds with a fused tricyclic
structure of coumarin and furan rings. They are commonly found in bioactive natural …

Recent advances in molecular genetics of furanocoumarin synthesis in higher plants

F Bourgaud, A Olry, A Hehn - Recent advances in redox active plant and …, 2014 - Springer
Furanocoumarins are important plant defense compounds, which are mainly found in four
higher plant families: Apiaceae, Moraceae, Fabaceae, and Rutaceae. These molecules …