Tryptophan catabolites, inflammation, and insulin resistance as determinants of chronic fatigue syndrome and affective symptoms in long COVID

HK Al-Hakeim, A Khairi Abed… - Frontiers in Molecular …, 2023 - frontiersin.org
Critical COVID-19 disease is accompanied by depletion of plasma tryptophan (TRY) and
increases in indoleamine-dioxygenase (IDO)-stimulated production of neuroactive …

[HTML][HTML] Histamine potentiates SARS-CoV-2 spike protein entry into endothelial cells

S Raghavan, MD Leo - Frontiers in Pharmacology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus
disease (COVID-19) is one of the most serious global health crises in recent history. COVID …

The growing understanding of the Pituitary implication in the pathogenesis of long COVID-19 syndrome: a narrative review

A Taieb, BHS Nassim, G Asma, M Jabeur… - … in Respiratory Medicine, 2024 - mdpi.com
Highlights What are the main findings? COVID-19 may lead to sequelae extending beyond
the acute phase of infection, characterized by fatigue and cognitive impairments, forming a …

Unexpected BP sensitivity to angiotensin II in a patient with coronavirus disease 2019, ARDS, and septic shock

H Wang, S Das, PM Wieruszewski, J Taji, B Bartlett… - Chest, 2020 - Elsevier
We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who
presented with ARDS and septic shock. The patient had exquisite BP sensitivity to low-dose …

[HTML][HTML] A clinical primer for the expected and potential post-COVID-19 syndromes

B Walitt, E Bartrum - Pain reports, 2021 - journals.lww.com
In late 2019, a novel coronavirus SARS-CoV-2 (COVID-19) spread unchecked across the
world's population. With tens of millions infected, the long-term consequences of COVID-19 …

Tachykinin: recent developments and novel roles in health and disease

T Onaga - Biomolecular concepts, 2014 - degruyter.com
Over 80 years has passed since the discovery of substance P (SP), and a variety of peptides
of the tachykinin (TK) family have been found and investigated. SP, neurokinin A (NKA), and …

Inflammatory reflex disruption in COVID‐19

K Hajiasgharzadeh, M Jafarlou… - Clinical and …, 2022 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) was identified in Wuhan,
China, in late 2019 and caused coronavirus disease 2019 (COVID‐19), which is still a …

[引用][C] Counter-regulatory renin-angiotensin system: An important line of research to understand and limit the severity of COVID-19

C Annweiler, Z Cao, N Papon… - … Current Drug Targets …, 2022 - ingentaconnect.com
Recent evidence on inefficacy and poor tolerance of (hydroxy) chloroquine as a therapeutic
option for COVID-19 gives rise to less toxic treatment research for COVID-19. An attractive …

COVID-19 and Lung Mast Cells: The Kallikrein–Kinin Activation Pathway

S Nagashima, AA Dutra, MP Arantes, RC Zeni… - International Journal of …, 2022 - mdpi.com
Mast cells (MCs) have relevant participation in inflammatory and vascular hyperpermeability
events, responsible for the action of the kallikrein–kinin system (KKS), that affect patients …

SARS-CoV-2 receptor is co-expressed with elements of the kinin–kallikrein, renin–angiotensin and coagulation systems in alveolar cells

D Sidarta-Oliveira, CP Jara, AJ Ferruzzi, MS Skaf… - Scientific reports, 2020 - nature.com
Abstract SARS-CoV-2, the pathogenic agent of COVID-19, employs angiotensin converting
enzyme-2 (ACE2) as its cell entry receptor. Clinical data reveal that in severe COVID-19 …