Analysis of mRNA expression and DNA methylation datasets according to the genomic distribution of CpG sites in osteoarthritis
P Yi, X Xu, J Yao, B Qiu - Frontiers in Genetics, 2021 - frontiersin.org
Objectives Transcriptional changes in cartilage can impact function by causing degradation
such as that which occurs during the development of osteoarthritis (OA). Epigenetic …
such as that which occurs during the development of osteoarthritis (OA). Epigenetic …
Analysis of methylation datasets identified significantly changed genes and functional pathways in osteoarthritis
B Han, Z Zheng, J Ren, W Qiu, X Li - Clinical Rheumatology, 2019 - Springer
Background Researches indicate that epigenetics was involved in osteoarthritis (OA). The
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …
purpose of this study was to describe the alterations of DNA methylation in hip and knee OA …
Genome-wide DNA methylation study of hip and knee cartilage reveals embryonic organ and skeletal system morphogenesis as major pathways involved in …
E Aref-Eshghi, Y Zhang, M Liu, PE Harper… - BMC musculoskeletal …, 2015 - Springer
Background Evidence suggests that epigenetics plays a role in osteoarthrits (OA). The aim
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …
of the study was to describethe genome wide DNA methylation changes in hip and knee OA …
Genome wide DNA methylation profiling of osteoarthritic articular cartilage
Purpose: To elucidate functional methylation profiles, with respect to gene expression, in
osteoarthritis (OA) affected and preserved articular cartilage in patients who underwent a …
osteoarthritis (OA) affected and preserved articular cartilage in patients who underwent a …
Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage
MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2014 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify DNA methylation
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …
changes in osteoarthritic (OA) cartilage tissue. Methods The contribution of differentially …
Use of integrative epigenetic and mRNA expression analyses to identify significantly changed genes and functional pathways in osteoarthritic cartilage
A He, Y Ning, Y Wen, Y Cai, K Xu, J Han… - Bone & joint …, 2018 - boneandjoint.org.uk
Aim Osteoarthritis (OA) is caused by complex interactions between genetic and
environmental factors. Epigenetic mechanisms control the expression of genes and are …
environmental factors. Epigenetic mechanisms control the expression of genes and are …
Identification of differentially methylated regions in new genes associated with knee osteoarthritis
Epigenetic changes in articular chondrocytes are associated with osteoarthritis (OA) disease
progression. Numerous studies have identified differentially methylated cytosines in OA …
progression. Numerous studies have identified differentially methylated cytosines in OA …
Effect of DNA methylation on gene transcription is associated with the distribution of methylation sites across the genome in osteoarthritis
P Yi, X Xu, J Yao, B Qiu - … and Therapeutic Medicine, 2021 - spandidos-publications.com
Genetics and epigenetics are important subjects in the field of osteoarthritis (OA) research.
DNA methylation may affect gene transcription, but the specific mechanisms have remained …
DNA methylation may affect gene transcription, but the specific mechanisms have remained …
[HTML][HTML] Genome-wide DNA methylation profile implicates potential cartilage regeneration at the late stage of knee osteoarthritis
Y Zhang, N Fukui, M Yahata, Y Katsuragawa… - Osteoarthritis and …, 2016 - Elsevier
Objective The aim of this work was to characterize the genome-wide DNA methylation profile
of cartilage from three regions of tibial plateau isolated from patients with primary knee …
of cartilage from three regions of tibial plateau isolated from patients with primary knee …
Genome‐wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage
MA Jeffries, M Donica, LW Baker… - Arthritis & …, 2016 - Wiley Online Library
Objective To perform a genome‐wide DNA methylation study to identify differential DNA
methylation patterns in subchondral bone underlying eroded and intact cartilage from …
methylation patterns in subchondral bone underlying eroded and intact cartilage from …