[HTML][HTML] The flaxseed-derived lignan phenolic secoisolariciresinol diglucoside (SDG) protects non-malignant lung cells from radiation damage

A Velalopoulou, S Tyagi, RA Pietrofesa… - International journal of …, 2015 - mdpi.com
Plant phenolic compounds are common dietary antioxidants that possess antioxidant and
anti-inflammatory properties. Flaxseed (FS) has been reported to be radioprotective in …

Radioprotective role in lung of the flaxseed lignan complex enriched in the phenolic secoisolariciresinol diglucoside (SDG)

M Christofidou-Solomidou, S Tyagi… - Radiation …, 2012 - meridian.allenpress.com
While dietary wholegrain Flaxseed (FS) has potent anti-inflammatory, anti-fibrotic and
antioxidant properties in murine models of acute and chronic lung injury, the main bioactive …

Dietary flaxseed prevents radiation-induced oxidative lung damage, inflammation and fibrosis in a mouse model of thoracic radiation injury

JC Lee, R Krochak, A Blouin, S Kanterakis… - Cancer biology & …, 2009 - Taylor & Francis
Flaxseed (FS) has high contents of omega-3 fatty acids and lignans with antioxidant
properties. Its use in preventing thoracic X-ray radiation therapy (XRT)-induced …

Gossypetin, a naturally occurring hexahydroxy flavone, ameliorates gamma radiation-mediated DNA damage

A Khan, K Manna, C Bose, M Sinha… - … Journal of Radiation …, 2013 - Taylor & Francis
Purpose: To evaluate the protective effect of gossypetin (GTIN) against gamma (γ)-radiation-
mediated DNA damage. Materials and methods: Increasing concentrations (10–150 μM) of …

Grape seed pro‐anthocyanidins ameliorates radiation‐induced lung injury

Y Huang, W Liu, H Liu, Y Yang, J Cui… - Journal of cellular …, 2014 - Wiley Online Library
Radiation‐induced lung injury (RILI) is a potentially fatal and dose‐limiting complication of
thoracic radiotherapy. This study was to investigate the protective effects of grape seed pro …

[HTML][HTML] In vitro screening of radioprotective properties in the novel glucosylated flavonoids

H Yu, JS Haskins, C Su, A Allum… - International …, 2016 - spandidos-publications.com
Novel glucosyl flavonoids are developed by the addition of glucose to naturally occurring
flavonoids. Flavonoids are known antioxidants that possess radioprotective properties. In …

[HTML][HTML] Radiation mitigating properties of the lignan component in flaxseed

R Pietrofesa, J Turowski, S Tyagi, F Dukes, E Arguiri… - BMC cancer, 2013 - Springer
Background Wholegrain flaxseed (FS), and its lignan component (FLC) consisting mainly of
secoisolariciresinol diglucoside (SDG), have potent lung radioprotective properties while not …

Protective Activity of C-Geranylflavonoid Analogs from Paulownia tomentosa against DNA Damage in 137Cs Irradiated AHH-1Cells

HI Moon, MH Jeong, WS Jo - Natural Product …, 2014 - journals.sagepub.com
Radiotherapy is an important form of treatment for a wide range of cancers, but it can
damage DNA and cause adverse effects. We investigated if the diplacone analogs of P …

[HTML][HTML] Synthetic secoisolariciresinol diglucoside (LGM2605) protects human lung in an ex vivo model of proton radiation damage

A Velalopoulou, S Chatterjee, RA Pietrofesa… - International journal of …, 2017 - mdpi.com
Radiation therapy for the treatment of thoracic malignancies has improved significantly by
directing of the proton beam in higher doses on the targeted tumor while normal tissues …

[HTML][HTML] Protective effect of fisetin (3, 7, 3', 4'-tetrahydroxyflavone) against γ-irradiation-induced oxidative stress and cell damage

MJ Piao, KC Kim, S Chae, YS Keum… - Biomolecules & …, 2013 - ncbi.nlm.nih.gov
Ionizing radiation can induce cellular oxidative stress through the generation of reactive
oxygen species, resulting in cell damage and cell death. The aim of this study was to …