The additive protective effects of hypothermia and chemical cardioplegia during ischemic cardiac arrest in the rat

DJ Hearse, DA Stewart, MV Braimbridge - The Journal of Thoracic and …, 1980 - Elsevier
In a rat heart model of cardiopulmonary bypass and ischemic cardiac arrest the potential
additive protective effects of hypothermia and chemical cardioplegia have been …

Protection of the acutely injured heart—deleterious effects of hypothermia

W Ting, AJ Spotnitz, JW Mackenzie, WH Chen… - Journal of Surgical …, 1994 - Elsevier
This experimental study was undertaken to evaluate the hypothesis that cardioplegic arrest
at 37° C is superior to 10° C cardioplegic arrest in the myocardial protection of an acutely …

The additive protective effects of hypothermia and chemical cardioplegia during ischemic cardiac arrest in the dog

FL Rosenfeldt, DJ Hearse, S Canković-Darracott… - The Journal of Thoracic …, 1980 - Elsevier
In clinical use cardioplegia is usually combined with local cardiac hypothermia, whose
powerful protective effects make it difficult to assess the contributions made by the …

Age-related changes in the ability of hypothermia and cardioplegia to protect ischemic rabbit myocardium

JE Baker, LE Boerboom, GN Olinger - The Journal of Thoracic and …, 1988 - Elsevier
Hypothermia combined with pharmacologic cardioplegia protects the globally ischemic adult
heart, but this benefit may not extend to children; poor postischemic recovery of function and …

Assessment of hypothermic, cardioplegic protection of the global ischemic canine myocardium

ML Hess, SM Krause, LJ Greenfield - The Journal of Thoracic and …, 1980 - Elsevier
Global ischemic arrest was induced in the canine myocardium under normothermic (35° to
37° C), hypothermic (8° to 12° C), and hypothermic plus cardioplegic conditions (30 mEq K+ …

Metabolic evidence that regional hypothermia induced by cold saline protects the heart during ischemic arrest

KS Rao, RW Schutz, H Feinberg, S Levitsky - Journal of Surgical Research, 1976 - Elsevier
The rationale for cold saline induced hypothermic myocardial protection during ischemic
cardioplegia has been limited for the most part to empiric and contractility observations. The …

Does lower systemic temperature enhance cardioplegic myocardial protection?

FL Grover, JG Fewel, JJ Ghidoni, JK Trinkle - The Journal of Thoracic and …, 1981 - Elsevier
This study was performed to determine if systemic temperature affects the rate of cooling and
rewarming of the myocardium between infusions of cold potassium cardioplegic solution …

Cardioplegia and myocardial preservation during cardiopulmonary bypass.

RM Engelman, S Levitsky, MJ O'Donoghue, J Auvil - Circulation, 1978 - europepmc.org
A standard experimental protocol was developed to explore the role of hypothermia and
potassium cardioplegia in myocardial preservation during 120 minutes of ischemic arrest …

Protection of the myocardium against postischemic reperfusion damage: the combined effect of hypothermia and nifedipine

WG Nayler - The Journal of Thoracic and Cardiovascular Surgery, 1982 - Elsevier
This study tests the hypothesis that the efficacy of hypothermia as a cardiacprotective agent
can be increased by adding the slow channel-blocking agent, nifedipine. Isolated …

Temperature-response studies of the detrimental effects of multidose versus single-dose cardioplegic solution in the rabbit heart

T Murashita, DJ Hearse - The Journal of thoracic and cardiovascular …, 1991 - Elsevier
Both single-dose and multidose cardioplegia are protective in the ischemic adult heart under
normothermic and hypothermic conditions, but in the hypothermic neonatal rabbit heart …