Accurate measurement of allele frequencies between population groups with differing
sensitivities to disease is fundamental to genetic epidemiology. Genotyping errors can …

Results The CRC was diagnosed in 50 individuals, and 200 patients were included in the
control group. Cases and controls were matched for mean age and sex (p> 0.05). Factors …

Purpose Variation in genetic factors together with xenobiotic exposure may result in
increased risk of colorectal cancer. The P-glycoprotein (P-gp) is highly expressed in the …

Background The multidrug resistance (MDR) 1 gene encodes a 170-kDa membrane
transporter called P-glycoprotein, which plays an important role in protecting cells against …

Crohn disease (CD) and ulcerative colitis (UC) are overlapping chronic inflammatory bowel
diseases (IBDs). Suggestive evidence for linkage at chromosome 7q has been reported for …

The three functional single-nucleotide polymorphisms (SNPs) of the MDR1 gene, C1236T,
G2677T/A, and C3435T, exhibit an interpopulation difference. In this study, we analyzed the …

Objectives There are suggestions that the MDR1 (ABCB1) gene is associated with ulcerative
colitis (UC) in Caucasians. We investigated whether common MDR1 variants were …

ATP Binding Cassette B1 (ABCB1) is a transporter with a broad substrate specificity involved
in the elimination of several carcinogens from the gut. Several polymorphic variants within …

Several lines of evidence suggest a role for the multidrug resistance gene (ABCB1/MDR1)
and its product, P-glycoprotein 170, in the pathogenesis of inflammatory bowel disease …

Background Smoking, dietary factors, and alcohol consumption are known life style factors
contributing to gastrointestinal carcinogenesis. Genetic variations in carcinogen handling …