CCSVI deconstructed and discarded

F Barkhof, MP Wattjes - Nature Reviews Neurology, 2013 - nature.com
Chronic cerebrospinal venous insufficiency (CCSVI) has been proposed as a cause of
multiple sclerosis (MS). However, two new studies found a very low overall prevalence of …

Review and analysis of international Case-Control Studies on CCSVI and multiple sclerosis

C Krogias, G Tsivgoulis, M Grond, HP Hartung… - 2013 - mediatum.ub.tum.de
Background: A constellation of neurosonological findings called chronic cerebrospinal
venous insufficiency (CCSVI) was introduced as a highly specific and highly sensitive …

CCSVI and MS: no meaning, no fact

C Baracchini, M Atzori, P Gallo - Neurological Sciences, 2013 - Springer
A condition called “chronic cerebrospinal venous insufficiency”(CCSVI) has been postulated
to play a role in the pathogenesis of multiple sclerosis (MS). This hypothesis implies that a …

Chronic cerebrospinal venous insufficiency is not associated with multiple sclerosis and its severity: a blind-verified study

MA Leone, O Raymkulova, P Naldi, P Lochner… - PLoS …, 2013 - journals.plos.org
Background Chronic Cerebrospinal Venous Insufficiency (CCSVI) has been associated with
multiple sclerosis (MS) with a risk ranging from as high as two-hundred-fold to a protective …

CCSVI is associated with multiple sclerosis

S Morovic, P Zamboni - Neurological research, 2012 - Taylor & Francis
Objectives: To analyze all the arguments against chronic cerebrospinal venous insufficiency
(CCSVI) as a medical entity, and its association with multiple sclerosis (MS) and to revise all …

[HTML][HTML] Chronic cerebrospinal venous insufficiency in multiple sclerosis: a historical perspective

MD Dake, R Zivadinov, EM Haacke - Functional neurology, 2011 - ncbi.nlm.nih.gov
Chronic cerebrospinal venous insufficiency (CCSVI) is a term used to describe impaired
venous drainage from the central nervous system (CNS) caused by abnormalities in …

Chronic cerebrospinal venous insufficiency (CCSVI) and multiple sclerosis (MS): a critical review

C Zecca, C Gobbi - … (Formerly Current Drug Targets-CNS & …, 2011 - ingentaconnect.com
Multiple sclerosis (MS) is a chronic disease of the central nervous system with not yet
completely understood pathogenesis. The so called “chronic cerebrospinal venous …

Chronic cerebrospinal venous insufficiency: case–control neurosonography results

AD Barreto, SA Brod, TT Bui, JR Jemelka… - Annals of …, 2013 - Wiley Online Library
Objective Chronic cerebrospinal venous insufficiency (CCSVI) has been implicated in the
pathophysiology of multiple sclerosis (MS). We sought to determine whether …

Evidence against the involvement of chronic cerebrospinal venous abnormalities in multiple sclerosis. A case-control study

IW Rodger, D Dilar, J Dwyer, J Bienenstock, A Coret… - PLoS …, 2013 - journals.plos.org
Objective Multiple sclerosis (MS) is a chronic neurodegenerative disease of the CNS.
Recently a controversial vascular hypothesis for MS, termed chronic cerebrospinal venous …

Italian multicentre observational study of the prevalence of CCSVI in multiple sclerosis (CoSMo study): rationale, design, and methodology

G Comi, MA Battaglia, A Bertolotto, M Del Sette… - Neurological …, 2013 - Springer
Chronic cerebro-spinal venous insufficiency (CCSVI) has been proposed as a “congenital
malformation” implicated in the pathogenesis of multiple sclerosis (MS). However, numerous …