For gap junction channels to function, their subunit proteins, referred to as connexins, have
to be synthesized and inserted into the cell membrane in their native configuration. Like …

Several different gap junction channel subunit isotypes, known as connexins, were
synthesized in a cell-free translation system supplemented with microsomal membranes to …

Gap junction channels assemble as dodecameric complexes, in which a hexameric
connexon (hemichannel) in one plasma membrane docks end-to-end with a connexon in …

Intercellular communication is mediated by gap junction (GJ) membrane channels that allow
ions, small signalling molecules and metabolites (4 kDa) to move rapidly and directly …

The formation of gap junctions is a multistep process that begins with synthesis in the
membrane of the endoplasmic reticulum (ER) of connexins (Cx), members of a highly …

Gap junction membrane channels assemble as dodecameric complexes, in which a
hexameric hemichannel (connexon) in one plasma membrane docks end to end with a …

To study the assembly of gap junctions, connexin-green-fluorescent-protein (Cx-GFP)
chimeras were expressed in COS-7 and HeLa cells. Cx26-and Cx32-GFP were targeted to …

Central to understanding the establishment and regulation of gap junction-mediated
intercellular communication is a detailed knowledge of how these complex structures are …

Trafficking pathways underlying the assembly of connexins into gap junctions were
examined using living COS-7 cells expressing a range of connexin-aequorin (Cx-Aeq) …

The biogenesis of connexins and their assembly into functional gap junction hemichannels
(connexons) was studied with the use of a cell-free transcription/translation system. Velocity …