We have recently shown that upregulation of glutamate transporter 1 (GLT1) in the brain is
associated in part with reduction in ethanol intake in alcohol-preferring (P) male rats. In this …

Glucagon-like-peptide-1 (GLP-1) is a gut-and neuro-peptide with an important role in the
regulation of food intake and glucose metabolism. Interestingly, GLP-1 receptors (GLP-1R) …

The neurochemical mechanisms that regulate development of alcohol use disorder (AUD)
are complex, and gut-brain peptides were recently pinpointed as novel modulators. Gut …

Given the limited efficacy of available pharmacotherapies for treatment of alcohol use
disorder (AUD), the need for new medications is substantial. Preclinical studies have shown …

The incretin hormone, glucagon‐like peptide 1 (GLP‐1), regulates gastric emptying, glucose‐
dependent stimulation of insulin secretion and glucagon release, and GLP‐1 analogs are …

Objectives: This study aims to explore the weight loss effect and safety of semaglutide as a
conventional anti-obesity drug systematically in obese or overweight patients without …

Background: Recently, a simple procedure in mice, Drinking‐in‐the‐Dark (DID), was
hypothesized to have value for medication development for human alcoholism. In DID, mice …

Purpose This meta-analysis aimed to assess the efficacy and safety of once-weekly
semaglutide among adults with overweight or obesity. Methods We searched multiple …

Introduction Semaglutide, a peptidic GLP-1 receptor agonist, has been clinically approved
for treatment of type 2 diabetes mellitus and is available in subcutaneous and oral dosage …

Rationale An increasingly compelling literature points to a major role for the glutamate
system in mediating the effects of alcohol on behavior and the pathophysiology of …