Hyperlipidemia-induced osteoporosis is marked by increased bone marrow adiposity, and
treatment with statins for hyperlipidemia often leads to new-onset osteoporosis. Endosome …

Background LincGAS5 have been reported to regulate the progression of osteoporosis (OP).
However, the relationship between LincGAS5 and reactive oxygen species (ROS) in …

Diabetic osteoporosis is a common complication in diabetic patients, leading to increased
fracture risk and impaired bone healing. As a member of the peroxisome proliferator …

Objective Obesity is a global health concern with management strategies encompassing
bariatric surgery and anti-obesity drugs; however, concerns regarding complexities and side …

It is known that excessive adipogenesis contributes to osteoporosis, suggesting that trans-
differentiation of adipogenic committed preadipocytes into osteoblasts may be a potential …

Mesenchymal stem cells (MSCs), also known as multipotent stromal cells, are used in
clinical trials. However, the use of MSCs for medical treatment of patients poses a potential …

Background Obesity has received increasing attention because of its widespread worldwide
occurrence and many threats to health. Human adipose-derived mesenchymal stem cells …

Background Osteoporosis is a prevalent metabolic bone disease in older adults.
Peroxisome proliferator-activated receptor β (PPARβ), the most abundant PPAR isotype …

Peroxisome proliferator activated receptor gamma (PPARγ) controls both glucose
metabolism and an allocation of marrow mesenchymal stem cells (MSCs) toward osteoblast …

Previous, we found that the small molecules capable of inhibiting the expression and the pro-
adipogenic activity of ZNF521 might improve the osteogenic performance of aging human …