Peripheral arterial disease (PAD) is a major health care problem. There have been limited
advances in medical therapies, and a huge burden of symptomatic patients with intermittent …

The prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million
people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is …

Therapeutic angiogenesis utilizing genetic and cellular modalities in the treatment of arterial
obstructive diseases continues to evolve. This is, in part, because the mechanism of …

Peripheral artery disease (PAD) poses a great challenge to society, with a growing
prevalence in the upcoming years. Patients in the severe stages of PAD are prone to …

Background Peripheral artery disease (PAD) is associated with a high clinical and
socioeconomic burden. Treatments to alleviate the symptoms of PAD and decrease the risks …

Peripheral arterial disease (PAD) is caused by occlusive atherosclerosis in a vascular bed
other than the heart. The lower extremity is the most-common location for PAD. Critical limb …

Highlights•The goal of angiogenesis in PAD is formation of collateral circulation.•It may be
particularly useful for patients no deemed candidates for revascularization.•Angiogenic …

We aim to determine the efficacy and safety of gene and cell angiogenic therapies in the
treatment of peripheral arterial disease (PAD) and evaluate them for the first time by a meta …

The physiological processes of angiogenesis, vasculogenesis and arteriogenesis contribute
to the growth of collateral vessels in response to obstructive arterial disease causing lower …

Currently, no effective pharmacological treatment is available for vascularisation defects in
lower limbs. Many patients presenting with persistent pain and ischaemic ulcers are not …