Microneedles (MN s) are micron‐sized, minimally invasive devices that breach the
outermost layer of the skin, the stratum corneum (SC), creating transient, aqueous pores in …

Human skin is a multilayered physiochemical barrier protecting the human body. The
stratum corneum (SC) is the outermost keratinized layer of skin through which only …

Drug delivery is often limited by the need to cross a barrier to gain access to target tissues. In
the case of skin, the main barrier is the skinLs outer layer of stratum corneum, which …

Microneedle (MN) patches consisting of miniature needles have emerged as a promising
tool to perforate the stratum corneum and translocate biomolecules into the dermis in a …

Microneedles (MNs) can be used for the topical treatment of skin disorders as they directly
deliver therapeutics to the site of skin lesions, resulting in increased therapeutic efficacy …

The skin is recognized as a potential target for local and systemic drug delivery and
hormone. However, the transdermal route of drug administration seems to be limited by …

The growing demand for patient-compliance therapies in recent years has led to the
development of transdermal drug delivery, which possesses several advantages compared …

Introduction: Transdermal drug delivery offers a number of advantages for the patient, not
only due to its non-invasive and convenient nature, but also due to factors such as …

The formidable barrier properties of the uppermost layer of the skin, the stratum corneum,
impose significant limitations for successful systemic delivery of broad range of therapeutic …

Drugs with poor oral bioavailability usually are administered by hypodermic injection, which
causes pain, poor patient compliance, the need for trained personnel, and risk of infectious …