DIsCussIon We present the case of a patient with a dual chamber pacemaker, taking
flecainide for paroxysmal atrial fibrillation, who presented with dehydration leading to acute …

We describe a case of a woman in her 80s with persistent atrial fibrillation (AF) despite being
on flecainide who was admitted for AF with rapid ventricular response. Attempts with direct …

Introduction: Flecainide toxicity (FT) is an uncommon yet potentially lethal complication. We
report a case of FT precipitated by acute kidney injury (AKI) in a patient with paroxysmal …

Purpose: Perhexiline (Px) has previously been utilized primarily in the treatment of otherwise
refractory angina pectoris and/or systolic heart failure. In recent years, Px has also shown …

Liver disease induced by perhexiline maleate Page 1 THE MEDICAL JOURNAL OF
AUSTRALIA the existence of depression demands treatment in its own right. As ECT is …

The ever-increasing burden of ischaemic heart disease and its common manifestation
chronic angina pectoris calls for the exploration of other treatment options for those patients …

What is known and objective Echinocandins are antifungal agents, routinely used in
invasive candida infections in critically ill patients. Their excellent anticandidal activity and …

We designed and synthesized perhexiline analogues that have the same therapeutic profile
as the parent cardiovascular drug but lacking its metabolic liability associated with CYP2D6 …

Background: The prognosis of severe symptomatic aortic stenosis is poor without aortic
valve replacement, with no previous reports of beneficial effects of any medical treatment on …

Discussion This case demonstrates that encephalopathy is a rare but serious side effect of
the class IC antiarrhythmic flecainide, although the mechanism of this side effect is not well …