Base editing induces single-nucleotide changes in the DNA of living cells using a fusion
protein containing a catalytically defective Streptococcus pyogenes Cas9, a cytidine …

Our ability to edit genomes lags behind our capacity to sequence them, but the growing
understanding of CRISPR biology and its application to genome, epigenome and …

Adenine base editors enable efficient targeted adenine-to-guanine single nucleotide
conversions to induce or correct point mutations in human cells, animals, and plants,,–. Here …

Cytosine base editors (CBEs) enable efficient, programmable reversion of T• A to C• G point
mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were …

Background As a result of its simplicity and high efficiency, the CRISPR-Cas system has
been widely used as a genome editing tool. Recently, CRISPR base editors, which consist …

Genome editing continues to revolutionize biological research. Due to its simplicity and
flexibility, CRISPR/Cas-based editing has become the preferred technology in most systems …

The ability to precisely edit individual bases of bacterial genomes would accelerate the
investigation of the function of genes. Here we utilized a nickase Cas9-cytidine deaminase …

Base editors have drawn considerable academic and industrial attention in recent years
because of their ability to alter single DNA bases with precision. However, the existing …

Deaminase base editing has emerged as a tool to install or correct point mutations in the
genomes of living cells in a wide range of organisms. However, the genome-wide off-target …

Many genetic diseases are caused by single-nucleotide polymorphisms. Base editors can
correct these mutations at single-nucleotide resolution, but until recently, only allowed for …