The entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into human
embryonic kidney (HEK293T) cells has been shown to be a cholesterol-rich, lipid raft …

The Niemann Pick C1 (NPC1) protein is an intracellular cholesterol transporter located in
the late endosome/lysosome (LE/Ly) and is involved in cholesterol mobilization. Loss-of …

Abstract Niemann-Pick type C1 (NPC1) receptor is an endosomal membrane protein that
regulates intracellular cholesterol traffic. This protein has been shown to play an important …

The novel human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2), emerged in Wuhan, China in late 2019 and has now caused a global pandemic …

The COVID-19 plague is hitting mankind. Several viruses, including SARS-CoV-1, MERS-
CoV, EBOV, and SARS-CoV-2, use the endocytic machinery to enter the cell. Genomic …

Despite the growing list of identified SARS-CoV-2 receptors, the human angiotensin-
converting enzyme 2 (ACE2) is still viewed as the main cell entry receptor mediating SARS …

Lipid rafts in cell plasma membranes play a critical role in the life cycle of many viruses.
However, the involvement of membrane cholesterol-rich lipid rafts in the entry of severe …

After binding to its cell surface receptor angiotensin converting enzyme 2 (ACE2), severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the host cell through directly …

Two recently published studies published in Science by Daly et al. 1 and Cantuti-Castelvetri
et al. 2 identified neuropilin-1 (NRP1) as an additional cellular mediator which may facilitate …

Membrane lipids and proteins form dynamic domains crucial for physiological and
pathophysiological processes, including viral infection. Many plasma membrane proteins …