ACE2-dependent and-independent SARS-CoV-2 entries dictate viral replication and inflammatory response during infection
Excessive inflammation is the primary cause of mortality in patients with severe COVID-19,
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …
yet the underlying mechanisms remain poorly understood. Our study reveals that ACE2 …
Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry
The outbreak of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has created
a global health crisis. SARS-CoV-2 infects varieties of tissues where the known receptor …
a global health crisis. SARS-CoV-2 infects varieties of tissues where the known receptor …
TRPC3-Nox2 Protein Complex Formation Increases the Risk of SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through ACE2 Upregulation
Y Kato, K Nishiyama, J Man Lee, Y Ibuki, Y Imai… - International journal of …, 2022 - mdpi.com
Myocardial damage caused by the newly emerged coronavirus (SARS-CoV-2) infection is
one of the key determinants of COVID-19 severity and mortality. SARS-CoV-2 entry to host …
one of the key determinants of COVID-19 severity and mortality. SARS-CoV-2 entry to host …
SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption
M Alruwaili, S Armstrong, T Prince, M Erdmann… - Journal of …, 2023 - Am Soc Microbiol
ABSTRACT SARS-CoV-2 emerged in the human population in late 2019, and human-to-
human transmission has dominated the evolutionary landscape and driven the selection of …
human transmission has dominated the evolutionary landscape and driven the selection of …
SARS coronavirus entry into host cells through a novel clathrin-and caveolae-independent endocytic pathway
While severe acute respiratory syndrome coronavirus (SARS-CoV) was initially thought to
enter cells through direct fusion with the plasma membrane, more recent evidence suggests …
enter cells through direct fusion with the plasma membrane, more recent evidence suggests …
SARS-CoV-2 down-regulates ACE2 through lysosomal degradation
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes its Spike (S)
glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular …
glycoprotein to bind to the angiotensin-converting enzyme 2 (ACE2) receptor for cellular …
[HTML][HTML] Severe respiratory SARS-CoV2 infection: Does ACE2 receptor matter?
SARS-CoV-2 is a novel virus of the Coronaviridiae family that represents a major global
health issue. Mechanisms implicated in virus/host cells interaction are central for cell …
health issue. Mechanisms implicated in virus/host cells interaction are central for cell …
Exploring the Syndecan-Mediated Cellular Internalization of the SARS-CoV-2 Omicron Variant
SARS-CoV-2 variants evolve to rely more on heparan sulfate (HS) for viral attachment and
subsequent infection. In our earlier work, we demonstrated that the Delta variant's spike …
subsequent infection. In our earlier work, we demonstrated that the Delta variant's spike …
Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication
LI Labzin, KY Chew, K Eschke, X Wang, T Esposito… - bioRxiv, 2022 - biorxiv.org
Macrophages are key cellular contributors to COVID-19 pathogenesis. Whether SARS-CoV-
2 can enter macrophages, replicate and release new viral progeny remains controversial …
2 can enter macrophages, replicate and release new viral progeny remains controversial …
Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2
L Xu, D Yu, M Xu, LX Yang, QC Zou, XL Feng, MH Li… - bioRxiv, 2024 - biorxiv.org
Coronavirus disease 2019 (COVID-19) is an immune-related disorder caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 invades cells via the …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 invades cells via the …