The transport of nucleic acid-based reagents is predicated upon developing structurally
stable delivery systems that can preferentially bind and protect DNA and RNA, and release …

Conspectus Silica-based nanoparticles (SNPs) are a classic type of material employed in
biomedical applications because of their excellent biocompatibility and tailorable …

Silica nanoparticles (SiNPs) have been widely engineered for biomedical applications, such
as bioimaging and drug delivery, because of their high tunability, which allows them to …

Advances in gene therapy have been foreshadowing its potential for the treatment of a vast
range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and …

The application of nanotechnology to biomedical research is expected to have a major
impact leading to the development of new types of diagnostic and therapeutic tools. One …

The use of nucleic acid to control the expression of genes relevant to tumor progression is a
key therapeutic approach in cancer research. Therapeutics based on nucleic acid provide …

Surface-functionalized mesoporous silica nanoparticles (MSNP) can be used as an efficient
and safe carrier for bioactive molecules. In order to make the MSNP a more efficient delivery …

Nucleic acids, including DNA, microRNA (miRNA), small interfering RNA (siRNA), and
antisense oligonucleotide (ASO), are powerful gene regulators, which have been …

Cellular delivery of DNA using silica nanoparticles has attracted great attention. Typically,
polyethyleneimine (PEI) is used to form a silica/PEI composite vector. Understanding the …

Silica-based nanoparticles are promising carriers for gene delivery applications. To gain
insights into the effect of particle size on gene transfection efficiency, amine-modified …