Our previous study indicated that interleukin (IL)-1β induces expression of several Wnt
proteins in chondrocytes and causes chondrocyte dedifferentiation via the c-Jun/activator …

Interleukin (IL)-1β is a major catabolic cytokine that plays a pivotal role in cartilage
destruction. This study examined the possible involvement and regulatory mechanisms of …

Proper longitudinal growth of long bones relies on the regulation of specific spatial patterns
of chondrocyte proliferation and differentiation. We have studied the roles of two members of …

Although regulation of chondrogenesis and cartilage development by Wnt signaling is well
established, the function of Wnt in the maintenance and destruction of cartilage remains …

We investigated the molecular mechanisms underlying canonical Wnt‐mediated regulation
of chondrocyte hypertrophy using chick upper sternal chondrocytes. Replication competent …

Osteoarthritis is the most prevalent form of arthritis in the world and it is becoming a major
public health problem. Osteoarthritic chondrocytes undergo morphological and biochemical …

Wnt proteins are expressed during limb morphogenesis, yet their role and mechanism of
action remains unclear during long bone growth. Wnt expression, effects and modulation of …

Summary Objective Aberrant Wnt signaling may contribute to osteoarthritis (OA) but the Wnt
family members involved have not been fully identified. The purpose of this study was to …

Wnt signaling has been implicated in the regulation of limb mesenchymal chondrogenesis.
In this study, we have analyzed the molecular mechanism of Wnt-7a inhibition of …

Articular cartilage is a physiologically non-self-renewing avascular tissue with a unique cell
type, the chondrocyte, which functions as producing and maintaining the extracellular matrix …