Acute pancreatitis (AP) is a potentially lethal inflammatory disease that lacks specific
therapy. Damaged pancreatic acinar cells are believed to be the site of AP initiation. The …

The recent findings illuminate a critical role of organelles regulating the autophagic,
endolysosomal, mitochondrial, and ER pathways in maintaining pancreatic acinar cell …

Pancreatitis is an increasingly common and sometimes severe disease that lacks a specific
therapy. The pathogenesis of pancreatitis is still not well understood. Calcium (Ca 2+) is a …

Acute pancreatitis represents a local inflammatory disorder with severe systemic
consequences. Significant progress in understanding the pathophysiology of acute …

Knowledge of the molecular mechanisms of acute pancreatitis is largely based on studies
using rodents. To assess similar mechanisms in humans, we performed ex vivo pancreatitis …

Recent advances challenge the long-believed trypsin-centered understanding of
pancreatitis. It is becoming increasingly clear that activation of intense inflammatory …

Acute pancreatitis is an increasingly common and sometimes severe disease for which there
is little specific therapy. Chronic pancreatitis is a common and grossly debilitating sequel …

Significance: Acute pancreatitis is an inflammatory disease of exocrine pancreas that carries
considerable morbidity and mortality; its pathophysiology remains poorly understood. During …

Acute pancreatitis is an inflammatory disorder of the exocrine pancreas associated with
tissue injury and necrosis. The disease can be mild, involving only the pancreas, and …

Pancreatic fibrosis is caused by excessive deposition of extracellular matrixes of collagen
and fibronectin in the pancreatic tissue as a result of repeated injury often seen in patients …