Cancer stem cells (CSCs) play major roles in cancer initiation, progression, and metastasis.
It is evident from growing reports that PI3K/Akt/mTOR and Sonic Hedgehog (Shh) signaling …

Activation of the sonic hedgehog (SHh) pathway is required for the growth of numerous
tissues and organs and recent evidence indicates that this pathway is often recruited to …

Background Recent evidence from in vitro and in vivo studies has demonstrated that
aberrant reactivation of the Sonic Hedgehog (SHH) signaling pathway regulates genes that …

Multiple lines of evidence suggest that the Sonic Hedgehog (Shh) signaling pathway is
aberrantly reactivated in pancreatic cancer stem cells (CSCs). The objectives of this study …

Background Pancreatic cancer is one of the most lethal malignancies. The innovative
treatments are required and now the cancer stem cells (CSCs) are expected to be an …

Activation of sonic hedgehog (Shh) in cancer stem cell (CSC) has been demonstrated with
aggressiveness of pancreatic cancer. In order to enhance the biological activity of α …

Pancreatic cancer is one of the most aggressive solid malignancies prone to metastasis.
Epithelial-mesenchymal transition (EMT) contributes to cancer invasiveness and drug …

The current investigation was intended to elucidate the molecular mechanism of α‐
Mangostin in the regulation of pancreatic cancer stem cell (CSC) characteristics. Here, we …

Dysregulation of the sonic hedgehog (Shh) signaling pathway has been associated with
cancer stem cells (CSC) and implicated in the initiation of pancreatic cancer. Pancreatic …

The biological function of long non‑coding RNA00261 (Linc00261) has been widely
investigated in various types of cancer. The aim of the present study was to explore the role …