Combined Targeting of AKT and mTOR Inhibits Tumor Formation of EpCAM+ and CD90+ Human Hepatocellular Carcinoma Cells in an Orthotopic Mouse Model
M Moustafa, KK Dähling, A Günther, L Riebandt… - Cancers, 2022 - mdpi.com
Simple Summary Cancer stem cells are a distinct tumor subpopulation associated with poor
outcome. The epithelial cell adhesion molecule (EpCAM) and Thy-1 cell surface antigen …
outcome. The epithelial cell adhesion molecule (EpCAM) and Thy-1 cell surface antigen …
[HTML][HTML] Carcinogenetic initiation contributed by EpCAM+ cancer cells in orthotopic HCC models of immunocompetent and athymic mice
H Pandit, Y Li, Q Zheng, W Guo, Y Yu, S Li… - Oncotarget, 2020 - ncbi.nlm.nih.gov
Purpose: Overexpression of epithelial cell adhesion molecule (EpCAM) correlates with poor
prognosis, therapeutic failure and early tumor recurrence in hepatocellular carcinoma (HCC) …
prognosis, therapeutic failure and early tumor recurrence in hepatocellular carcinoma (HCC) …
[PDF][PDF] Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma
T Yamashita, M Honda, Y Nakamoto, M Baba… - …, 2013 - Wiley Online Library
Recent evidence suggests that hepatocellular carcinoma (HCC) is organized by a subset of
cells with stem cell features (cancer stem cells; CSCs). CSCs are considered a pivotal target …
cells with stem cell features (cancer stem cells; CSCs). CSCs are considered a pivotal target …
Sorafenib suppresses extrahepatic metastasis de novo in hepatocellular carcinoma through inhibition of mesenchymal cancer stem cells characterized by the …
M Yoshida, T Yamashita, H Okada, N Oishi, K Nio… - Scientific Reports, 2017 - nature.com
Cancer stem cells (CSCs) are a pivotal target for eradicating hepatocellular carcinoma
(HCC). We previously reported that distinctive CSCs regulating tumorigenicity (EpCAM+ …
(HCC). We previously reported that distinctive CSCs regulating tumorigenicity (EpCAM+ …
[HTML][HTML] CD133+ EpCAM+ phenotype possesses more characteristics of tumor initiating cells in hepatocellular carcinoma Huh7 Cells
Y Chen, D Yu, H Zhang, H He, C Zhang… - … journal of biological …, 2012 - ncbi.nlm.nih.gov
Background: EpCAM or CD133 has been used as the tumor initiating cells (TICs) marker in
hepatocellular carcinoma (HCC). We investigated whether cells expressing with both …
hepatocellular carcinoma (HCC). We investigated whether cells expressing with both …
Targeting cancer stem cells in hepatocellular carcinoma
The poor outcome of patients with hepatocellular carcinoma (HCC) is attributed to
recurrence of the disease after curative treatment and the resistance of HCC cells to …
recurrence of the disease after curative treatment and the resistance of HCC cells to …
Expression of CD90/EpCAM/CD24 in hepatocellular carcinoma cell lines at various stages of differentiation
BD Chen, YF Hui, HB Zhang, LF Fan… - Zhonghua gan Zang …, 2013 - europepmc.org
Objective To confirm the malignant phenotype of hepatocarcinoma cell (HCC) lines at
various stages of differentiation (MHCC97L, MHCC97H and HCCLM3) and to explore their …
various stages of differentiation (MHCC97L, MHCC97H and HCCLM3) and to explore their …
[HTML][HTML] De novo emergence of mesenchymal stem-like CD105+ cancer cells by cytotoxic agents in human hepatocellular carcinoma
Y Nomura, T Yamashita, N Oishi, K Nio, T Hayashi… - Translational …, 2017 - Elsevier
BACKGROUND: Cancer stem cells (CSCs) are considered a pivotal target for the
eradication of hepatocellular carcinoma (HCC). Recently, we reported that the CSC markers …
eradication of hepatocellular carcinoma (HCC). Recently, we reported that the CSC markers …
[HTML][HTML] Prognostic value of the expression of cancer stem cell-related markers CD133 and CD44 in hepatocellular carcinoma: from patients to patient-derived tumor …
Q Zhao, H Zhou, Q Liu, Y Cao, G Wang, A Hu, L Ruan… - Oncotarget, 2016 - ncbi.nlm.nih.gov
High expression of cancer stem cell (CSC) markers is related to poor prognosis of patients
with hepatocellular carcinoma (HCC). However, the expression of these markers in patient …
with hepatocellular carcinoma (HCC). However, the expression of these markers in patient …
Expression of cancer stem cell markers EpCAM and CD90 is correlated with anti-and pro-oncogenic EphA2 signaling in hepatocellular carcinoma
N Asakura, N Nakamura, A Muroi, Y Nojima… - International journal of …, 2021 - mdpi.com
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide.
Additionally, the efficacy of targeted molecular therapies with multiple tyrosine kinase …
Additionally, the efficacy of targeted molecular therapies with multiple tyrosine kinase …