Human histocompatibility leukocyte antigen (HLA)-DM is a facilitator of antigen presentation
via major histocompatibility complex (MHC) class II molecules. In the absence of HLA-DM …

Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …

DM facilitates formation of high affinity complexes of peptide–major histocompatibility
complex (MHC) by release of class II MHC–associated invariant chain peptide (CLIP). This …

The nonclassical major histocompatibility complex class II molecule HLA-DM (DM) has
recently been shown to play a central role in the class II-associated antigen presentation …

Major histocompatibility complex (MHC) class II–positive cell lines which lack HLA-DM
expression accumulate class II molecules associated with residual invariant (I) chain …

HLA-DM catalyzes the release of invariant chain fragments from newly synthesized major
histocompatibility complex (MHC) class II molecules, stabilizes empty class II molecules, and …

Considerable progress has been made in the field of major histocompatibility complex
(MHC) class II-restricted antigen presentation. The analysis of mutant cell lines defective in …

Abstract HLA-DM (DM) edits major histocompatibility complex class II (MHCII)-bound
peptides in endocytic compartments and stabilizes empty MHCII molecules. Crystal …

Abstract HLA-DM removes CLIP and other loosely bound peptides from MHC class II
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …

Human leukocyte antigen (HLA)-DM is a critical participant in antigen presentation that
catalyzes the release of class II-associated invariant chain-derived peptides (CLIP) from …