Vascularized composite tissue allotransplantation–state of the art

JR Diaz‐Siso, EM Bueno, GC Sisk… - Clinical …, 2013 - Wiley Online Library
Vascularized composite tissue allotransplantation is a viable treatment option for injuries
and defects that involve multiple layers of functional tissue. In the past 15 yr, more than 150 …

Vascularized composite allografts and solid organ transplants: similarities and differences

A Weissenbacher, T Hautz, J Pratschke… - Current opinion in …, 2013 - journals.lww.com
We herein summarize the progress made in VCA in the last year with a focus on new clinical
immunosuppressive strategies and novel targets for immunosuppression and …

Large animal models of vascularized composite allotransplantation: a review of immune strategies to improve allograft outcomes

AJ Matar, RL Crepeau, GS Mundinger… - Frontiers in …, 2021 - frontiersin.org
Over the past twenty years, significant technical strides have been made in the area of
vascularized composite tissue allotransplantation (VCA). As in solid organ transplantation …

Vascularized composite allograft‐specific characteristics of immune responses

F Issa - Transplant International, 2016 - Wiley Online Library
Vascularized composite allograft (VCA) transplantation, or reconstructive transplantation,
has revolutionized the treatment of complex tissue and functional defects. Despite arriving …

Composite tissue allotransplantation: opportunities and challenges

J Iske, Y Nian, R Maenosono, M Maurer… - Cellular & molecular …, 2019 - nature.com
Vascularized composite allotransplants (VCAs) have unique properties because of diverse
tissue components transplanted en mass as a single unit. In addition to surgery, this type of …

Vascularized composite allotransplantation: medical complications

MC Uluer, PS Brazio, JD Woodall, AJ Nam… - Current transplantation …, 2016 - Springer
The objective of this review is to summarize the collective knowledge regarding the risks and
complications in vascularized composite tissue allotransplantation (VCA), focusing on upper …

Vascularized composite allotransplantation: towards tolerance and the importance of skin-specific immunobiology

DA Leonard, JM Kurtz, CL Cetrulo Jr - Current Opinion in Organ …, 2013 - journals.lww.com
The majority of VCA centers utilize antibody-mediated induction, followed by double or triple-
agent maintenance immunosuppression. A clinical trial of a minimal-immunosuppression …

Vascularized composite allotransplant in the realm of regenerative plastic surgery

H Chim, H Amer, S Mardini, SL Moran - Mayo Clinic Proceedings, 2014 - Elsevier
Vascularized composite allotransplant (VCA) has led to new treatment options for patients
with severe upper extremity and facial injuries. Although VCA can restore form and function …

The need for inducing tolerance in vascularized composite allotransplantation

KV Ravindra, H Xu, LD Bozulic… - Journal of …, 2012 - Wiley Online Library
Successful hand and face transplantation in the last decade has firmly established the field
of vascularized composite allotransplantation (VCA). The experience in VCA has thus far …

Vascularized composite allotransplantation: an update on medical and surgical progress and remaining challenges

BD Murphy, RM Zuker, GH Borschel - Journal of Plastic, Reconstructive & …, 2013 - Elsevier
Background In vascularized composite allotransplantation, multiple types of tissue are
transferred from donor to recipient as a single functional unit. This technique has been …