Challenges and opportunities for immunotherapeutic intervention against myeloid immunosuppression in glioblastoma
MA Exley, S Garcia, A Zellander, J Zilberberg… - Journal of Clinical …, 2022 - mdpi.com
Glioblastoma multiforme (GBM), the most common and deadly brain cancer, exemplifies the
paradigm that cancers grow with help from an immunosuppressive tumor microenvironment …
paradigm that cancers grow with help from an immunosuppressive tumor microenvironment …
Role of myeloid cells in the immunosuppressive microenvironment in gliomas
CV Locarno, M Simonelli, C Carenza, A Capucetti… - Immunobiology, 2020 - Elsevier
Glioma is the most common primary brain cancer, and half of patients present a diagnosis of
glioblastoma (GBM), its most aggressive and lethal form. Conventional therapies, including …
glioblastoma (GBM), its most aggressive and lethal form. Conventional therapies, including …
[HTML][HTML] Immunosuppression in glioblastoma: current understanding and therapeutic implications
Glioblastoma (GBM) is the most common primary brain tumor in adults an carries and carries
a terrible prognosis. The current regiment of surgical resection, radiation, and chemotherapy …
a terrible prognosis. The current regiment of surgical resection, radiation, and chemotherapy …
Understanding the immunosuppressive microenvironment of glioma: mechanistic insights and clinical perspectives
Glioblastoma (GBM), the predominant and primary malignant intracranial tumor, poses a
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …
formidable challenge due to its immunosuppressive microenvironment, thereby confounding …
Mechanism and therapeutic potential of tumor-immune symbiosis in glioblastoma
Glioblastoma (GBM) is the most aggressive and lethal form of brain tumor in human adults.
Myeloid-lineage cells, including macrophages, microglia, myeloid-derived suppressor cells …
Myeloid-lineage cells, including macrophages, microglia, myeloid-derived suppressor cells …
Myeloidcells in the immunosuppressive microenvironment in glioblastoma: The characteristics and therapeutic strategies
B Huang, J Zhang, W Zong, S Chen, Z Zong… - Frontiers in …, 2023 - frontiersin.org
Glioblastoma (GBM) is the most common and lethal malignant tumor of the central nervous
system in adults. Conventional therapies, including surgery, radiotherapy, and …
system in adults. Conventional therapies, including surgery, radiotherapy, and …
Immunosuppression mechanisms and immunotherapy strategies in glioblastoma
Gliomas are brain tumors that arise from neuroglial progenitor cells in the brain, which have
an annual incidence rate of around six per 100,000 people in the US (Ostrom et al., 2013) …
an annual incidence rate of around six per 100,000 people in the US (Ostrom et al., 2013) …
The role of myeloid cells in GBM immunosuppression
Gliomas are intrinsic brain tumors that originate from glial cells. Glioblastoma (GBM) is the
most aggressive glioma type and resistant to immunotherapy, mainly due to its unique …
most aggressive glioma type and resistant to immunotherapy, mainly due to its unique …
The emerging role of myeloid-derived suppressor cells in the glioma immune suppressive microenvironment
Y Mi, N Guo, J Luan, J Cheng, Z Hu, P Jiang… - Frontiers in …, 2020 - frontiersin.org
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid
progenitor and precursor cells at different stages of differentiation, which play an important …
progenitor and precursor cells at different stages of differentiation, which play an important …
Immunotherapy for glioblastoma: current progress and challenges
MW Yu, DF Quail - Frontiers in immunology, 2021 - frontiersin.org
Glioblastoma is a highly lethal brain cancer with a median survival rate of less than 15
months when treated with the current standard of care, which consists of surgery …
months when treated with the current standard of care, which consists of surgery …